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Background: According to the National Institutes of Health, translation is defined by NCATS as turning observations in the laboratory, clinic and community into interventions that improve the health of individuals and communities. Translational Science is the field of investigation focused on understanding the scientific and operational principles underlying each step of the translation process. A
Wake Forest University School of Medicine, the academic core of Atrium Health, is hosting a virtual conference on October 14th which will bring together thought leaders from academic health centers that have adopted the LHS concept and expanded their approach to clinical care, research and education, to reflect the principles and practices of LHS. The virtual session will include panel discussions
The Wake Forest School of Medicine and Atrium Health enterprise is a top 50 national academic medical center and world class health system with an extramurally funded research portfolio of over $300M annually. We bring together high-quality health care with innovative research as an academic learning health system with the goal of improving the health of our patients and communities we serve. The
The Wake Forest Clinical and Translational Science Institute is working to nurture the academic Learning Health System (aLHS) at Wake Forest. Each of the CTSI’s unique programs were tasked to pivot a portion of their work specifically to this aim. In doing such, a collaboration formed among the Biostatistics, Epidemiology, and Research Design (BERD), Team Science, and Translational Pilot Programs
KL2 awardees from Clinical and Translational Science Centers (CTSA) present virtual lectures as part of the CTSA Visiting Scholar Program. Kirsten M. Wright, ND, MCR, MS from Oregon Health and Science University hosted by Wake Forest School of Medicine will present her research on "Using a Home-Based Monitoring Platform to Explore Real-World Routines and Nutrition Behavior in Older Adults at Risk
Wake Forest demonstrates how a health care system can more quickly turn research outcomes into patient care with a new blood pressure measurement protocol that may help prevent strokes and cardiovascular events.
Equipping Faculty at Wake Forest and Beyond When asked the vision behind CTSI’s Mentor Academy, Claudia Olivier, PhD responded: “Every mentor needs some level of training on how to be a good—a great—mentor.” Dr. Olivier serves as co-facilitator of the 6-month Mentor Academy cohorts alongside faculty Program Leader Debra Diz, PhD. Initially created for mid-career faculty, the Mentor Academy has
What's a Research Studio? CTSI’s Team Science Program created the Research Studio to meet the sometimes difficult-to-define needs around crafting grant proposals, finding collaborators, and fleshing out study teams. How will the study be designed? Is the hypothesis clear and succinct, yet robust enough to make a meaningful impact? How will the trial be implemented, measured, and finally translated
The porphyrias are a group of rare, inherited disorders, each caused by a deficiency with one of eight enzymes necessary to produce heme, an important component of hemoglobin and other proteins. The porphyrias are classified as either acute hepatic (liver) or cutaneous (skin); the former is characterized generally by acute attacks of severe abdominal pain accompanied by nausea, vomiting and other
Focal and Segmental Glomerulosclerosis, Minimal Change Disease, and Membranous Nephropathy, presenting as Nephrotic Syndrome (NS), are a group of rare renal diseases that may cause serious complications and end-stage kidney disease, generating significant individual, societal and economic burdens. The Nephrotic Syndrome Study Network (NEPTUNE) brings together physician scientists at 26 sites in
Eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis are disorders in which a type of immune cell (called eosinophils) builds up in the digestive tract, causing gastrointestinal tissue damage. These disorders are painful, lifelong, and make it hard or impossible for people to eat many or all foods. The Consortium of Eosinophilic Gastrointestinal
Amyotrophic lateral sclerosis (ALS) is a fatal disease that involves progressive death of motor nerves in the brain, brainstem, and spinal cord. The disease is closely related to disorders such as primary lateral sclerosis, hereditary spastic paraplegia, progressive muscular atrophy, and frontotemporal dementia. These diseases have shared genetic causes and underlying biology as well as a shared
During this unprecedented time of the COVID-19 pandemic, Wake Forest’s Clinical and Translational Science Institute (CTSI) has navigated significant challenges the pandemic has presented to best support our research community. Our poster will communicate several areas where our CTSI has promoted COVID-19 research activities, facilitated the implementation of research new policies impacted by COVID
The Appalachian Translational Research Network (ATRN) is a 501©3 composed of academic institutions, community organizations, and individuals committed to translational research and training that addresses health disparities and inequities across the Appalachian region. Appalachia is a large, geographically-defined area of the eastern United States that has a history of significant health
Kylie Kavanagh, Matthew J. Jorgensen, J. Mark Cline, D. McClain The goal of Wake Forest (WF) Nonhuman Primate (NHP) Signature Program is to accelerate translational research by providing access to the ultimate translational animal model. NHP have served as an extremely successful preclinical platform that has allowed the bidirectional flow of knowledge from scientists to clinicians and back to