Mayo Clinic

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    Mayo Clinic Center for Clinical and Translational Science

    Mayo Clinic Center for Clinical and Translational Science (CCaTS) connects researchers to the people, information and resources they need to keep medical science moving forward. CCaTS is a central hub for institutional advancement of research and education at Mayo Clinic. The center provides tools and expert consultation to support every aspect of medical research, including basic discovery science, clinical and community-engaged research, and late-stage application and commercialization.
  • No champion race car driver can win without a dedicated pit crew. The same is true in medical research. Thanks to their “pit crew” Mayo Clinic researchers were able to repurpose an experimental therapy, called lenzilumab, for patients with COVID-19 pneumonia, and from there into a phase three clinical trial — all in about one year. "I think we’ve accomplished in this year what normally would take

  • “It was surreal, it seemed like this day would never come at times,” says Jacqueline Zayas, of the many hours spent in the lab and classroom working toward her M.D., and Ph.D. For as long as she could remember, Dr. Zayas, who hails from Miami, Fla., says she would tell her family that she wanted to become a doctor. The M.D. - Ph.D. program, offered by the Mayo Clinic Center for Clinical and

  • Clinical trials help researchers discover and apply critical advances in patient care. Clinical trials follow rigorous scientific processes that usually take many years to complete. However, during the COVID-19 pandemic, people have been able to see and experience clinical trials operating on fast-forward. And a lot of people are wondering, "How do clinical trials work?" In this Q&A, the Mayo

  • Children are underrepresented and understudied in clinical trials, limiting the number of children-focused research studies and the overall advancement of pediatric medicine. To address this, Mayo Clinic researchers established a first-of-its-kind Pediatric Advisory Board to engage youth as partners in research and enhance pediatric research participation. A description of the board and results of

  • Community engagement is the bridge that connects researchers and local communities; however, face-to-face engagement is often limited in reach and scale — especially during a pandemic. In a recently published paper, researchers from Mayo Clinic and the University of Minnesota evaluated the feasibility of a virtual statewide Facebook community platform to enhance public trust and engagement with

  • The action of an immune cell called a neutrophil may contribute to tissue aging, according to a new study. As neutrophils do their job, they may damage chromosomes in nearby cells which, over time, may lead to cellular senescence. This new concept may help clarify cell aging. It also suggests targeting neutrophils might be helpful in treatment of age-related disease. This research was funded, in

  • Monica Albertie leads a small but mighty team of four research operations and program managers at Mayo Clinic, and they have a very important charge: Keep Mayo health equity research running full steam at all times. The team, part of the Center for Health Equity and Community Engagement Research, supports dozens of research teams across Mayo Clinic. The team helps researchers write protocols and

  • U.S. public health officials report that the COVID-19 pandemic has disproportionately affected communities that have been medically underserved, leading to higher infection and mortality rates. A Mayo Clinic study recently published in the American Journal of Public Health says easy access to rapid testing is needed to combat disparities, and a community-driven and culturally tailored strategy is

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    Sjӧgren's syndrome (SS), the second most common rheumatic disease contributing nine times the cost of a healthy person, has hallmark features of oral and ocular dryness due to salivary and lacrimal gland inflammation. Minor salivary glands, central to the pathogenesis and diagnosis of SS, contain mesenchymal stromal cells (MSCs). In other conditions MSCs are responsible for tissue repair and

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    Mayo Clinic

    Almost all cardiovascular variables that have been assessed at different times of day and night in humans have been found to have a day/night pattern, including blood pressure heart rate, and vascular endothelial function. These patterns result from the summation of predictable circadian effects with variable behavioral (e.g. sleep, exercise, and meal intake) and environmental (e.g. temperature)

  • Esophageal cancer is relatively rare, making up only about 1% of cancer cases diagnosed each year in the U.S. Mayo Clinic researchers have found that esophageal adenocarcinoma, a type of esophageal cancer, has been rising in incidence over the past 40 years, particularly among people under 50. More concerning is that these younger patients tend to be diagnosed when the cancer is already at a more

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    Fundamentals of Clinical and Translational Science (FunCaTS) is a combination of 13 online modules strategically packaged together to enable medical professionals and allied health staff to expand their knowledge of the components of clinical and translational research. These components provide the fundamental knowledge to promote understanding of the process of bringing discoveries to the bedside

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    Are you ready to take a deeper dive into the world of clinical and translational science? Essentials of Clinical and Translational Science (ECaTS) provides medical professionals with foundational knowledge of research terminology, research methods and processes, clinical epidemiology, and biomedical statistics. Upon completion, learners understand basic terminology and methodological concepts in

  • Black churches have long been strongholds for sharing trusted health information with their communities, and never has that role been more important than during the COVID-19 pandemic. A new paper details how Mayo researchers are working with Black churches in MN to address COVID-19 health disparities.

  • Vasculitis Clinical Research Consortium

    Vasculitis refers to a group of rare diseases that involve inflammation of blood vessels, which disrupts blood flow and often causes damage to the body’s organs. The cause of most forms of vasculitis remains unknown, and treatments involve the use of strong medications that can have serious side effects. The Vasculitis Clinical Research Consortium (VCRC) is an international, multicenter clinical

  • North American Mitochondrial Disease Consortium (NAMDC)

    Mitochondrial diseases affect approximately 1 in every 5,000 people. These diseases can cause muscle weakness, difficulty thinking, seizures, hearing and vision loss, digestive problems, learning disabilities, and organ failure. The North American Mitochondrial Disease Consortium (NAMDC) is a network of clinicians and researchers at 17 different clinical sites working to better understand

  • Nephrotic Syndrome Rare Disease Clinical Research Network III (NEPTUNE)

    Focal and Segmental Glomerulosclerosis, Minimal Change Disease and Membranous Nephropathy, presenting as Nephrotic Syndrome (NS), are a group of rare renal diseases that may cause serious complications and end-stage kidney disease, generating significant individual, societal and economic burdens. The Nephrotic Syndrome Study Network (NEPTUNE) brings together physician scientists at 26 sites in the

  • Frontiers in Congenital Disorders of Glycosylation (FCDGC)

    Congenital disorders of glycosylation (CDG) consist of more than 130 different inborn errors of metabolism at an estimated overall incidence of greater than 1 in 100 000. While they were first genetically defined in the 1990s, there is no data available on natural history, no comprehensive patient registry, no reliable screening tests for many types, and large gaps in clinical trial readiness. In

  • Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

    Eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis and eosinophilic colitis are disorders in which a type of immune cells (called eosinophils) build up in the digestive tract, causing tissue damage to the esophagus, stomach or colon. These disorders are painful and lifelong, and they make it hard or impossible for people to eat many or all foods. The Consortium of

  • Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)

    Amyotrophic lateral sclerosis (ALS) is a fatal disease that involves progressive death of motor nerves in the brain, brainstem and spinal cord. The disease is closely related to disorders such as primary lateral sclerosis, hereditary spastic paraplegia, progressive muscular atrophy and frontotemporal dementia. These diseases have shared genetic causes and underlying biology. They also have in

  • Brain Vascular Malformation Consortium (BVMC)

    The Brain Vascular Malformation Consortium (BVMC) focuses on three rare brain conditions: familial cerebral cavernous malformation (CCM), Sturge-Weber syndrome (SWS), and hereditary hemorrhagic telangiectasia (HHT). These disorders are poorly understood, are costly to manage, and can cause serious complications such as hemorrhages, seizures, and problems with spinal cord, nerve or brain function

  • Mayo Clinic has launched a COVID-19 Vaccine Registry that will identify people interested in participating in upcoming COVID-19 vaccine clinical trials. People who add their name to the registry may be contacted in the future to determine if they are eligible to participate in a COVID-19 vaccine trial at Mayo Clinic.

  • A new study of living kidney donors at Mayo Clinic in Minnesota and Arizona from 1999 to 2018 has found some microstructural features that can indicate some long-term susceptibility for chronic kidney disease in otherwise healthy adults. The study, published in Mayo Clinic Proceedings, reinforces that kidney donation is safe for living donors, and it provides new insights for counseling donors on

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    The Mayo Clinic COVID-19 Task Force was established to enable, coordinate, and catalog research studies and practice demands of COVID-19. The task force manages research across the whole translational spectrum, aligning competing and duplicative studies to steward research resources and coordinates Institutional Review Board, Center for Clinical and Translational Science (CCaTS) Office of Clinical

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    Many clinical questions have arisen with the COVID-19 pandemic, from who is at greatest risk for COVID-19 infection to adverse outcomes if infected to how COVID-19 has impacted healthcare utilization patterns. To help answer these questions, and many more, the National COVID Cohort Collaborative (N3C) has integrated real-world clinical observations from across the nation into a harmonized database

  • A study recently published in the Journal of the American Medical Association points to a significant opportunity to improve health disparities training provided medical residents in U.S. internal medicine programs. Researchers from Mayo Clinic and other academic medical centers examined a data set that merged two national survey samples from 2015: internal medicine program director and internal

  • Nanodropper, co-founded by a Mayo Clinic Alix School of Medicine student, designed and makes a specialized eye drop bottle adapter that reduces medicine waste by delivering a more precise drop for patients and doctors. The team, led by CEO and third-year medical student Alissa Song, developed the precision eye dropper in 2017. Since then, the team has found success in business start-up

  • Mayo Clinic recently held virtual town hall meetings in Arizona to address community health needs related to COVID-19. Hundreds of people from local African American and Hispanic communities attended to learn important information to help their communities and to dispel harmful myths. Presenters cited statistics showing that minority communities are being disproportionately impacted by COVID-19

  • The virtual Jax Saludable Hispanic health conference, led by Mayo Clinic researchers, brought together more than 300 Hispanic leaders from across Jacksonville to discuss a shared vision to improve health care access, processes and outcomes for Hispanics in northeast Florida. “We have been told multiple times by our community partners that this effort is the first of its kind to address in a