Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)


The Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) is a clinical trials network funded by the National Institute for Neurological Disorders and Stroke (NINDS), the National Heart Lung and Blood Institute (NHLBI) and the National Center for Advancing Translational Science (NCATS). The goal of the SIREN Network is to improve the outcomes of patients with neurologic, cardiac, respiratory and hematologic emergencies by identifying effective treatments given in the earliest stages of care. The SIREN Network is composed of a Clinical Coordinating Center, a Data Coordinating Center and 11 SIREN Hubs. SIREN is a scalable network and operates with a hub and spoke structure with the ability to add more clinical sites (spokes) as needed for each individual clinical trial. In developing SIREN, the NIH has recognized that pre-clinical and translational research often demonstrates a critical early window of opportunity in which novel treatments for many emergencies are optimally effective and that conducting research in the emergency setting presents unique pragmatic challenges to clinical investigators. SIREN builds upon the success of the previous Neurologic Emergency Treatment Trials (NETT) network and incorporates expertise and experiences from the Resuscitation Outcome Consortium (ROC).