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Prioritize these line items post launch nor it's not hard guys bottleneck mice so baseline the procedure and samepage your department. Exposing new ways to evolve our design language code in an ideal world yet not enough bandwidth. You must be muted we need to have a Come to Jesus meeting with Phil about his attitude, and please submit the sop and uat files by next monday we need to leverage our

VCU Health featured two VCU researchers, both serving in community engagement roles at the VCU Wright Center for Clinical and Translational Research, for October’s Global Diversity Awareness Month. “Diversity matters in health care because it drives innovation,” said Katherine Tossas, Ph.D., M.S., whose work is informed by bioinformatics and community-engaged research. Tossas, the director of

A series of compounds discovered in the laboratory of Rockefeller’s Jan L. Breslow will be developed into novel medicines, the drug discovery company Bridge Medicines recently announced. These compounds have shown promise in treating immune-mediated conditions in animals, such as models of rheumatoid arthritis, without compromising the immune system and harming the rest of the body—a side effect

Jennifer Moss, Ph.D., an assistant professor of family and community medicine at Penn State College of Medicine, recently published research about the cancer screening rates of older Americans. She reported that many older Americans are receiving cancer screenings past recommended ages – a situation called overscreening. This study was partially supported by Penn State Clinical and Translational

From the early days of the COVID-19 pandemic, epidemiologist Melissa Haendel knew that the United States was going to have a data problem. There didn’t seem to be a national strategy to control the virus, and cases were springing up in sporadic hotspots around the country. With such a patchwork response, nationwide information about the people who got sick would probably be hard to come by. Other

As the pandemic wears on, doctors are learning more about how to better care for patients with COVID-19, but there is still so much to learn. Moreover, the long-term effects of the disease are unknown. So the NIH and its National Center for Advancing Translational Sciences (NCATS) have launched a National COVID Cohort Collaborative (N3C) to collect electronic health record (EHR) data from partners

Emily Zimmerman, Ph.D., M.S., MPH, wrote the book on community engaged research – literally. Released in March, “Researching Health Together: Engaging Patients and Stakeholders, From Topic Identification to Policy Change” features a collection of experiences from researchers across the country, sharing how and why their projects are designed to engage the community. The Wright Center sat down with

One of the most vexing aspects of the COVID-19 pandemic is the novel coronavirus’s ability to turn the body’s immune system against the body. After the virus has been cleared from the body, the immune system sometimes continues to hurtle an arsenal of immune proteins at the already vanquished virus, creating a dangerous inflammatory response called a cytokine storm. Such cytokine storms can

According to the American Foundation for Suicide Prevention, suicide is the 10th leading cause of death in the U.S., with over 1.4 million suicide attempts recorded in 2018. Although effective treatments are available for those at risk, clinicians do not have a reliable way of predicting which patients are likely to make a suicide attempt. Researchers at the Medical University of South Carolina

An award-winning smartphone app spearheaded by the University of Minnesota integrates a patient’s responses with the healthcare provider’s electronic health records (EHR) system.

For every two deaths attributed to COVID-19 in the U.S., a third American dies as a result of the pandemic, according to new data published in the Journal of the American Medical Association. The study, led by researchers at Virginia Commonwealth University, shows that deaths between March 1 and Aug. 1 increased 20% compared to previous years — maybe not surprising in a pandemic. But deaths

People are likely to experience kidney stones again after getting them the first time. By drinking more water, people can prevent the reappearance of kidney stones. Though this may seem easy, fewer than 50% of people who had kidney stones drink the recommended amount of fluids. A team of Penn State researchers recently received a five-year, $2.97 million grant from the National Institute of

Penn State Clinical and Translational Science Institute recently launched a podcast called Engage. Each podcast features a Penn State expert discussing the research process or how health research benefits the University's neighbors. “Education is an important mission for our institute,” Dr. Larry Sinoway, institute director, said. "We are always looking for new ways to share the translational

Story Transcript “It was not my intent to be involved at all, ever.” Bonnie Blue is Chicago’s first COVID-19 vaccine participant and one of more than 25,000 people who have volunteered for the Moderna vaccine trial so far. She didn’t intend to volunteer, but the rising death toll and an opportunity to save lives changed her mind. Blue says, “My people typically are not very trustful, but what I’m

Jennifer Rosenthal, assistant professor of clinical pediatrics, will begin a four-year K23 Mentored Patient-Oriented Research Career Development Award funded by the National Institute of Child Health and Human Development (NICHD) to study pediatric interfacility transfers. Pediatric interfacility transfers are frequent but poorly studied events. Dr. Rosenthal’s project, “Telemedicine Consultations

Stephanie Crossen, a pediatric endocrinologist and assistant professor of clinical pediatrics at UC Davis Health, will begin a four-year K23 training award funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Dr. Crossen will study several ways to leverage telehealth and connected health technology to improve care delivery and outcomes for children and

In late 2019, a report from the Brookings Institution named Madison, Wisconsin, as one of the top 35 metro areas with the potential to become America’s next top innovation hubs. That report included recommendations on how Congress could support the growth of such hubs, such as providing funding to support university research, business development, workforce development, regional planning and

N3C Domain Teams enable researchers with shared interests analyze data within the N3C Data Enclave and collaborate more efficiently in a team science environment. Multi-discipline Clinical Domain Teams comprised of clinical and subject matter experts, statisticians, informaticists, and machine learning specialists focus on clinical questions surrounding COVID-19's impact on health, whereas the

Researchers at Washington University School of Medicine in St. Louis have received a pair of grants totaling $11.3 million to study genetic and environmental factors that contribute to developmental disabilities and to find new ways to improve the lives of children and adults affected by such disabilities. The grants — a five-year award from the Eunice Kennedy Shriver National Institute of Child

Using state-of-the-art statistical methods, a team of researchers said they may have taken a leap closer to understanding a class of jumping genes, sequences that move to different locations in the human genome, which is the body’s complete set of DNA. They added that the work could lead to insights into the evolution of the human genome, as well as have implications for several diseases

Four UC Davis research centers will share a $3.7 million grant to offer free COVID-19 testing for agricultural workers in the Central Valley, where the coronavirus pandemic has reached alarming levels, the National Institutes of Health (NIH) announced Wednesday. The funding for the UC Davis Environmental Health Sciences Center, Clinical and Translational Science Center (CTSC), Center for Reducing

A team led by Manish Shah, MD, MPH, Professor of Emergency Medicine and Director of the KL2 Career Development Program at the University of Wisconsin Institute for Clinical and Translational Research (UW ICTR), will develop an advanced surveillance system to identify future waves of the COVID-19 pandemic and provide training to front-line providers. With funding from the Wisconsin Partnership

Taylor Ochalek, Ph.D., a postdoctoral research fellow at the VCU C. Kenneth and Dianne Wright Center for Clinical and Translational Research, sat with Miss America, Camille Schrier, to discuss the opioid crisis in light of Ochalek's recent JAMA paper showing an alarming surge of overdoses during the pandemic. “Across the U.S., COVID-19 has really disproportionately impacted underserved minority

Infectious disease expert Dr. Seble Kassaye, associate professor of medicine at Georgetown University Medical Center (GUMC) and former GHUCCTS KL2 scholar, led a team of researchers to develop an online COVID-19 symptom tracking tool. The tool ensures a person’s confidentiality while being able to actively monitor their symptoms. “Our online system provides a method for efficient, active

For the last two years, the National Hispanic Council on Aging (NHCOA) has partnered with the National Institutes of Health to raise awareness about the All of Us Research Program (AoU). The All of Us Research Program is inviting one million people across the U.S. to help build one of the most diverse health databases in history. NHCOA’s role in the AoU program is to raise awareness about health

The National Patient-Centered Clinical Research Network (PCORnet) is accelerating research that puts patient front and center. PCORnet has become a valuable resource at UNC-Chapel Hill. Story by Julie J. Novara

Trying to manage funding a lab while running a lab can be challenging for even the most experienced investigator. For Hong Chen, PhD, assistant professor of biomedical engineering at the McKelvey School of Engineering at Washington University in St. Louis and of radiation oncology at the School of Medicine, the ICTS provided invaluable assistance on her path to fund research on using ultrasound to

If you get COVID-19, go to your local academic research hospital. That’s what Margaret Lessard told her parents. “The pandemic really emphasized to me how going to an academic medical center opens up the possibilities for you as a patient,” said the senior clinical research coordinator at VCU Health. “We had treatments here that weren’t available anywhere else.” Lessard would know. She was part of

The COVID-19 pandemic has spurred interest in research on the pathogen in the context of social determinants, clinical practices, treatment options, and outcomes. This has created an urgent need to make data about the care of patients affected by COVID available to researchers. Electronic health records offer a rich source of information for clinical research studies, hypothesis generation, cohort

Nearly a month ago, we joined a Society for Research Administrators International (SRAI) “virtual happy hour” to discuss with colleagues the implications of the COVID-19 pandemic on Institutional Review Board (IRB) operations. We not only wanted to help and offer advice, but also wanted to learn and hear from others what they were going through during this time. The discussion began around

Electronic health records are painting a detailed picture of COVID-19 testing, infections, and hospitalizations. This statewide effort—which includes CTSI and several healthcare providers—could help identify disparities and inform interventions to improve outcomes for all Minnesotans.

We are all witnessing the immense impact that the COVID-19 situation is having on research activities across our institutions. The CTSC is particularly interested in how this pandemic is affecting clinical research professionals (CRPs) across the spectrum. We surveyed our CTSC-affiliated CRPs seeking to gain feedback and insight from their first-hand experiences. The CRPs who shared their

Officials from Hemex Health joined with supportive global health leaders to launch the company’s Gazelle® Diagnostic platform in time for World Sickle Cell Day which fell on Friday, June 19, 2020. Hemex Health started the development of Gazelle, with technology licensed from Case Western Reserve University. Researcher Dr. Umut Gurkan led studies into the technology in 2014 and said the key is its

Translational research aims to speed research breakthroughs into the clinic. And yet, training for basic scientists and clinicians too often remains siloed, leading to divergent cultures and a loss of opportunity for cross-disciplinary collaboration. The South Carolina Clinical & Translational Research (SCTR) Institute’s TL1 program, a translational research training program for doctoral students

Penn State Clinical and Translational Science Institute awarded funding to four projects with topics addressing at-risk populations or instituting prevention programs in healthcare as part of its Bridges to Translation Pilot Grant Program. Bridges to Translation invests in novel research ideas to promote collaboration across Penn State to collect information to lead to external funding and future

The Tillamook County Wellness (TCW) coalition, of which the Oregon CTSA (OCTRI) is a member and key supporter, scored a big win recently when Tillamook Adventist Health’s newly-created Community Well-Being Division absorbed TCW’s Wellness Coordinator position – as well as the person filling it – to head Adventist’s new Division. This move was an important step, because it confirms the importance

A mother and her three preschool-age children ran out of food as they self-isolated in rural Washington County, awaiting COVID-19 test results. They were far from a grocery store and had no transportation. The next day, on a hot July 2 afternoon, a volunteer pulled into their driveway to deliver emergency food aid. As the last box of food was placed on the doorstep, one of the children shouted

Sergio Aguilar-Gaxiola, director of the UC Davis Center for Reducing Health Disparities, has received a prestigious award from the Mexican government for his work in advocating for the rights of Mexican nationals in the United States. The recognition – known as the Ohtli Award – is the highest honor granted by the Mexican government to individuals who have dedicated their lives to improving the

In a paper published Friday by the Journal of the American Medical Association, Virginia Commonwealth University researchers released data showing an alarming surge in opioid-related overdoses during the COVID-19 pandemic. Nonfatal opioid overdose visits to the VCU Medical Center emergency department in Richmond increased from 102 between March and June 2019 to 227 between March and June 2020

The University of Rochester Clinical and Translational Science Institute (UR CTSI) was part of a community coalition that recently received an award for its highly-effective COVID-19 community outreach campaign. The campaign, dubbed “Six Feet Saves,” reached hundreds of thousands of residents across New York's Monroe County and emphasized the importance of social distancing to slow the spread of

With a new award from NIH, an interdisciplinary group led by Drs. Elizabeth Burnside and Jomol Mathew at the University of Wisconsin Institute for Clinical and Translational Research will develop a proof of concept data intake and management infrastructure, Real-time Access to Patient’s Integrated Data for COVID-19 (RAPID-COVID19). Under the auspices of the Clinical and Health Informatics

Evaluating clinical and translational research (CTR) mentored training programs is challenging because no two programs are alike. Clara Pelfrey, PhD and Kelli Qua, PhD took to the task of comparing bibliometrics between individuals and between programs and have published their results in the Journal of Clinical & Translational Science. The KL2 program provides mentored-training for early stage CTR

Our "Microbiome in Human Health and Disease" pilot funding awardee discusses his innovative research in wound healing Victor Neel, MD, PhD, is an assistant professor in dermatology at Massachusetts General Hospital. His project “Characterization of the skin microbiome during acute wound healing following surgery” was funded by our Translational Innovator program’s “Microbiome in Human Health and

A study recently published in the Journal of the American Medical Association points to a significant opportunity to improve health disparities training provided medical residents in U.S. internal medicine programs. Researchers from Mayo Clinic and other academic medical centers examined a data set that merged two national survey samples from 2015: internal medicine program director and internal

Frontiers: University of Kansas Clinical and Translational Science Institute recently selected four new awardees for its KL2 Mentored Career Development Program and three new awardees for its TL1 Trainee Program. As part of the Frontiers Education Core, KL2 awards provide a two-year tailored, mentored research experience to promising clinical and translational research faculty. The new Frontiers

Why don't we see more young girls with autism? To tackle this big, complicated question, Clare Harrop, PhD - a developmental psychologist at the University of North Carolina at Chapel Hill - started small with a TraCS $2K pilot award. Curious what you can do with such a small grant award? Harrop describes the $2K grant as a gateway that opened doors to many other opportunities. "I did not expect

Across the world, many years ago, doctors would prescribe unappealing concoctions of human and animal stool a treat a number of stomach ailments. And, in the last 10 years, clinical trials have begun to confirm why. “There’s really a factory inside our bellies,” says Jasmohan Bajaj, M.D., a gastroenterologist and liver specialist at Virginia Commonwealth University. “Anything that we eat or drink

Hailed for its ability to erase distance between health care providers in cities and patients in rural areas, telehealth has ironically enabled medical care to continue in a time when we all must keep our distance. Across the country, telehealth use has spiked as providers offer virtual patient visits to ensure medical needs are met while minimizing COVID-19 exposure. Regulatory agencies have

A protein highly expressed in lung cancer cells drives resistance to targeted therapies, report researchers at the Medical University of South Carolina in the Journal of Thoracic and Cardiovascular Surgery. In preclinical experiments, the researchers showed that inhibiting the protein caused the death of non-small cell lung cancer cells that had become resistant to therapy. The MUSC Team was led

The National Center for Advancing Translational Sciences (NCATS) and the National Center for Data to Health (CD2H) announce the launch of the National COVID Cohort Collaborative (N3C) Data Enclave. NIH also made a news release on Wednesday September 2, 2020. Faced with the urgent need to address the global pandemic, subject matter experts from the Clinical and Translational Science Awards (CTSA)

Storytelling is one of the most effective ways to share our experiences and impart meaning onto our world. Through stories, we can connect with others in different levels, learn something new or feel inspired to explore new ideas. At the Institute of Translational Health Sciences (ITHS) we have an opportunity to do this by sharing our own stories of innovation, successes, research, new projects

Nanodropper, co-founded by a Mayo Clinic Alix School of Medicine student, designed and makes a specialized eye drop bottle adapter that reduces medicine waste by delivering a more precise drop for patients and doctors. The team, led by CEO and third-year medical student Alissa Song, developed the precision eye dropper in 2017. Since then, the team has found success in business start-up

A study that found that L-type calcium channel blockers (LCCBs) — a widely used drug for treating high blood pressure — may harm the heart as much as help it, benefited from the use of Penn State Clinical and Translational Science Institute's research population discovery tool, TriNetX. Martin Johnson, a graduate student and study co-author, is a graduate of the institute's year-long Translational

Many of South Carolina’s nicotine addiction researchers are in Charleston. But many of the smokers who need to quit live elsewhere in the state. This poses a dilemma for researchers and smokers alike. Researchers can’t enroll large and representative groups of smokers into their trials. And smokers who would like to quit cannot easily access investigational treatments that could help them to do so

The North Carolina Clinical and Translational Sciences (NC TraCS) Institute is pleased to announce the opening of the application cycle for the following institutional junior faculty (K) career development programs: • Gene Orringer Junior Faculty Career Development (TraCS KL2) Program for early stage clinical and translational researchers • Oncology K12 for clinicians aspiring to an academic

Couples that include a partner with post-traumatic stress disorder (PTSD) may someday have access to a faster, more efficient therapy that treats the disorder and simultaneously improves their relationships, according to research. A study published by the journal Behavior Therapy demonstrated that an established treatment that typically involves 15 weekly sessions could be shortened to one weekend

Two Penn State faculty will learn how to better incorporate community input into their research programs through a Penn State Clinical and Translational Science Institute fellowship program. Wilson Brown, assistant professor of clinical psychology at Penn State Behrend and Casey Pinto, assistant professor of public health sciences at Penn State College of Medicine, are this year's Community

“Especially during the COVID-19 pandemic, our Diabetes Prevention program has become a lifeline for many Georgians. Participants look forward to this session as a way they can connect with others at a time when they’re missing out on that social connection. It’s helping them take stock in their nutrition and health behaviors. Our program has become a source of hope and encouragement for many. They

The Infectious Disease Clinical Research Unit at Washington University School of Medicine has launched the ACTIV-2 Outpatient Monoclonal Antibodies and Other Therapies Trial, which will be conducted by the AIDS Clinical Trials Group. The school’s Infectious Disease Clinical Research Unit is one of 25 initial sites conducting ACTIV-2, which includes both phase 2 and phase 3 evaluations of multiple

A new saliva test to detect the SARS-CoV-2 virus has been developed by researchers at Washington University School of Medicine in St. Louis. Results from the COVID-19 diagnostic test are available in a few hours and, ideally, able to be communicated to people tested within a day. Highly sensitive to detecting even tiny levels of the virus in a saliva sample, the test does not require special swabs

Rebecca Jennings thought the food had gone bad. Everything tasted terrible, and the retired teacher and guidance counselor knew something was off. “I was having trouble breathing, and then I started coughing. That's a sure sign with me,” said Jennings, who’s had a few bouts with pneumonia. “My daughter says I was delirious. I had no hunger, no thirst. I just wanted to sleep.” The 70-year-old had

William Powderly, MD, director Washington University Institute of Clinical and Translational Sciences, featured in recent episode of Washington University's School of Medicine's 'Show Me the Science' podcast on where the nation has come and where we may be headed as coronavirus infections and deaths continue to rise.

Nation’s Most Comprehensive Whole-Genome Screening Program Will Advance Inclusive Precision Medicine Across UCSF Health UC San Francisco scientists have launched a precision medicine initiative to offer free voluntary whole genome sequencing to all UCSF Health patients – making it the most comprehensive program of its kind in the nation. The goal of the initiative, called the UCSF 3D Health Study

The Translational Science Benefits Model (TSBM), created by the Institute of Clinical and Translational Sciences at Washington University in St. Louis, is a framework public health and clinical scientists use to demonstrate the impact of their work in the real world. First published September 8, 2017 in Clinical and Translational Science, TSBM was inspired by the desire to look beyond simple

Brain tumors are typically diagnosed using MRI imaging because taking a sample for a tissue biopsy is risky and may not be possible due to tumor location or a patient’s poor health conditions. Researchers at Washington University in St. Louis are developing a method to diagnose brain tumors without any incisions. The method is developed by a team led by Hong Chen, assistant professor of biomedical

Accelerating research has become more important than ever in the face of a global pandemic. By creating a model that meets the need for speed, the University of Minnesota can hasten the development of therapeutics—not just for one candidate, but for COVID-19 treatments being developed across UMN.

Today, a handful of Chicago residents will be the first in the city to participate in a national clinical trial to test a potential vaccine against SARS-CoV-2, the virus that causes COVID-19. The vaccine is an mRNA vaccine developed by Moderna, a Massachusetts-based biotech company. It is one of many vaccines in development but so far is one of the leading candidates being developed in the U.S

In response to the SARS-CoV-2 pandemic, over 250 Case Western Reserve University faculty teamed up to form the COVID Research Taskforce, under the direction of Dr. Jonathan Karn and Dr. Nora Singer, one of the co-leads of the CTSC of Cleveland’s Hub Research Capacity component. “The goal of this university-wide initiative is to attack the pandemic from many sides,” said Singer, “addressing a wide

Madisyn Elam knew she wanted to be a doctor. “I have a lot of family who were sick when I was growing up, so I was always in and out of the hospital with them,” Elam said. The Durham, North Carolina, native also enjoyed science in high school, so she majored in biology on a pre-medical track, graduating from Virginia State University earlier this year. Now, through a collaboration of universities

Children with autism born to mothers who had immune conditions during their pregnancy are more likely to have behavioral and emotional problems, a UC Davis Health study has found. The study examined maternal immune history as a predictor of symptoms in children with autism. “We tested the ability of maternal immune history to predict ASD symptoms and the possible role that the sex of the offspring

Patients at UC Davis Health today became the first in Sacramento to receive a vaccine candidate for COVID-19, which is part of a major clinical trial involving 30,000 participants worldwide. The six people who received the injection are part of a late-stage study that will enroll about 200 participants through UC Davis Health’s clinical trials program. “I’m excited about being able to be afforded

Dr. Amala Soumyanath, a former Oregon CTSA (OCTRI) scholar at Oregon Health & Science University, will establish and lead a botanical research center to study the properties of herbs traditionally used in dietary supplements to improve sleep and mood, and delay cognitive decline in aging. The research will inform high-quality clinical trials by increasing knowledge about the active compounds and

Deborah Chavis-Keeling, MS, is the Executive Director of Administration and Finance at the NYU–H+H Clinical and Translational Science Institute. Deb has been a part of the CTSI since its founding in June 2009, and before that at the GCRC since 2006. She is exceptionally positioned to describe how the CTSI was uniquely equipped to tackle the challenges faced through the COVID-19 pandemic. Why and

A research project that received critical early funding from Duke CTSI is now ready to enter the $1.1 billion hernia market.

New York City has been at the epicenter of the COVID-19 pandemic. At its peak, with over 6300 new cases and 590 deaths per day in New York City, Mount Sinai hospital underwent unprecedented changes to manage the enormous surge in COVID-19 patients. Many of our KL2 and TL1 scholars were redeployed or relocated to working from home. To determine the impact of these changes on the research training

AMIA and HL7 are partnering for the third year to bring an exciting application showcase to the AMIA 2020 Virtual Annual Symposium. AMIA 2020 is the place for you if you have to offer or are interested in an innovative FHIR®-based App working in practice! Submit Your FHIR® App! If you are working on FHIR® and have an App to show, we would like to hear from you! The Showcase is a fun, fast-paced

This course was created on short notice at the start of the heavy COVID patient influx at NYU Langone Health in March 2020. With only a weekend to prepare course materials, the didactic lectures began on March 31, 2020 with the first mentor session taking place on April 1st, under the leadership of Stuart Katz, MD, Helen L. and Martin S. Kimmel Professor of Advanced Cardiac Therapeutics and

Researchers at Michigan Medicine have teamed up to launch a study to test the safety and efficacy of the agent defibrotide to treat patients with COVID-19 illnesses.

Kathy White, an early COVID-19 patient at Virginia Commonwealth University medical center, has joined an oversight committee designed to bring the best treatment options to VCU Health system and the Richmond community. The COVID-19 Clinical Trials Oversight Committee, formed in April, brings together experts from across the health system and university to evaluate and prioritize drug treatment

The Oregon Clinical & Translational Clinical Research Institute (OCTRI) at Oregon Health & Science University (OHSU) funded three projects for their 2020 Biomedical Innovation Program drug discovery track. The funded research covers pancreatic cancer, prostate cancer, and SARS-CoV-2. This category of funding supports drug discovery platforms and early-stage therapeutic technology projects

The National Institutes of Health (NIH)’s Rapid Acceleration of Diagnostics (RADx) initiative has awarded contracts to seven biomedical diagnostic companies whose innovative technologies will increase the availability of COVID-19 tests by millions per week as early as September 2020. While expanding the nation’s testing capacity, these testing technologies use different methods including more

The Strategy What began as an effort to better define Virginia Commonwealth University’s key performance indicators in research turned into an all-encompassing database that enables performance data to be shared openly and that is designed to improve transparency as well as ease the administrative burden on principal investigators (PI) and study teams. VCU’s Wright Center for Clinical and

The Strategy The NYU H+H Clinical and Translational Science Institute recognized a need to improve its scientific review standards and practices and to make better use of resources at the institution and at its Institutional Review Board. In implementing the Common Metric Initiative (CMI), the hub developed a strategy to broaden its Scientific Review Committee to conduct pre-reviews of studies

Other medical crises haven’t taken a break during the COVID-19 pandemic. They’ve taken a back seat. And the four-month-long sidelining has become apparent, as data emerges about delayed medical treatment and death rates that exceed the virus’ reach. Virginia Commonwealth University researchers want to know more. How has the stress of the pandemic affected people with drug and alcohol addictions

Visiting interns from medical schools across the country showcase their research projects at virtual closing ceremony. Each July, Gordon Hall’s Waterhouse Room at Harvard Medical School (HMS) is the setting for student presentations of their mentored research project they participated in over the summer. This year, the room wasn’t filled with proud mentors and family applauding in the audience

A 2019 VRIP medical student describes the program’s meaningfulness and how COVID-19 has affected his medical education Ross O’Hagan was in the 2019 Visiting Research Internship Program (VRIP), a summer program for medical students designed to foster diversity and interest in clinical and translational research. He is now a rising third-year medical student at Icahn School of Medicine at Mount

Harvard Catalyst collaborations a key to pandemic progress. The Harvard Catalyst Connector program and its translational navigation teams have played an integral role on the research front within the Harvard Medical School (HMS) community over the past five months, assisting HMS researchers who were required to rapidly ramp down lab work and then safely restart research projects a few months later

Researchers at Washington University are using synthetic data to accelerate COVID-19 research and facilitate collaboration among healthcare institutions.

All current breast cancer drugs were first tested in cell lines. Each cell line began as cancer in a patient. As such, each cell line is a surrogate for that patient's disease. A new database of 40 breast cancer cell lines, developed by Medical University of South Carolina investigators, will help researchers deepen their understanding of these cell lines and speed the development of new gene

Size matters when it comes to research, as illustrated by recent debates about whether hydroxychloroquine is effective against COVID-19. Some small studies showed it was effective while others showed it wasn’t. The studies couldn’t arrive at a definitive answer because they didn’t enroll enough patients to reach sufficient statistical “power.” More relevant results are only now beginning to emerge

Older Americans may be receiving cancer screenings not recommended by the U.S. Preventive Services Task Force, according to Penn State College of Medicine researchers. The task force recommends routine screening for colorectal, cervical and breast cancers. These recommendations end for people at upper ages or who develop a condition that decreases their life expectancy. A routine screening above

After a competitive application cycle, GHUCCTS has selected 6 new pilot projects to be funded for 2020-2021. The Pilot Translational and Clinical Studies program (PTCS) has been a critical and effective stimulus for collaboration that has inspired the development and implementation of new clinical and translational research projects. The PTCS program is designed to bring about further advances

Originally published at UNC Health Talk. As the coronavirus disease 2019 (COVID-19) continues to wreak havoc in communities across the globe, researchers are racing to find successful treatments for the deadly virus and ideally, a vaccine against COVID-19. While it is understandable that everyone wants a miracle cure as soon as possible, it's not that easy. All new medical drugs and treatments

Mayo Clinic recently held virtual town hall meetings in Arizona to address community health needs related to COVID-19. Hundreds of people from local African American and Hispanic communities attended to learn important information to help their communities and to dispel harmful myths. Presenters cited statistics showing that minority communities are being disproportionately impacted by COVID-19

Philip R.O. Payne, PhD, director of the Institute for Informatics at Washington University School of Medicine in St. Louis, has been named associate dean for health information and data science, and chief data scientist for the School of Medicine. Payne, also the Janet and Bernard Becker Professor, will provide strategic oversight of a portfolio of programs and activities focused on creating and

A team of researchers including Dr. Jessica Ericson, Oluwamuyiwa "Winnie" Adebayo, Ph.D., Dr. Catharine Paules and Dr. Patrick Gavigan are evaluating the public’s knowledge and acceptance of health messaging related to COVID-19, such as social distancing and stay-at-home orders. The research team wants to understand better how the public processes, interprets and ultimately responds to this health

A research project allows residents of Penn State main campus's home county to share their pandemic experiences and participate in decision-making as the region moves forward. Penn State Clinical and Translational Science Institute is supporting Centre County COVID-19 Data 4 Action Project. The institute is providing both staffing support and the resources and services it provides the University

A team of Penn State and U.S. Food and Drug Administration researchers studying why certain stroke-causing blood clots cannot be removed benefited from an early investment by Penn State Clinical and Translational Science Institute. National Institutes of Health recently awarded a $2.49 million grant for the research project. "If we can understand more about these clots and the surrounding

The University of Rochester Medical Center (URMC) is joining researchers across the country to test whether transfusions of plasma from recovered COVID-19 patients (also called convalescent plasma) can prevent infection in healthy volunteers or speed recovery in people with mild COVID-19 infections. The trials, which are led nationally by Schmuel Shoham, M.D., and David Sullivan, M.D., at Johns

The virtual Jax Saludable Hispanic health conference, led by Mayo Clinic researchers, brought together more than 300 Hispanic leaders from across Jacksonville to discuss a shared vision to improve health care access, processes and outcomes for Hispanics in northeast Florida. “We have been told multiple times by our community partners that this effort is the first of its kind to address in a

Drawing on electronic health records from across its academic health system, University of California Health has developed a unified, secure data set for use in COVID-19 research. The HIPAA Limited Data Set consisting of clinical information with more than 460 million data points is accessible to researchers across the entire UC system, enabling them to rapidly compare treatment options from

Drawing on electronic health records from across its academic health system, University of California Health has developed a unified, secure data set for use in COVID-19 research. The HIPAA Limited Data Set consisting of clinical information with more than 460 million data points is accessible to researchers across the entire UC system, enabling them to rapidly compare treatment options from

Story courtesy of CBS News Black Americans already face health disparities, but added pressure from the pandemic and social unrest is compounding stress for many. Dr. Olu Ajilore, an associate professor in the Department of Psychiatry at the University of Illinois at Chicago and Clinical Research Center director for UIC's Center for Clinical and Translational Science, joins CBSN’s Lana Zak to talk

The North Carolina Translational and Clinical Sciences (TraCS) Institute, the integrated hub of the CTSA at the University of North Carolina at Chapel Hill, will have a research professional speak every Thursday 4:00 PM – 5:00 PM as part of a brand new series. TraCS Tales of Translation will feature experienced scientists from academia and industry discussing the many twists and turns that are a

The North Carolina Translational and Clinical Science Institute Inclusive Science Program (ISP) has recently launched the Rural Health Research Toolkit, a resource for researchers designing and conducting research focusing on rural communities. Rural populations experience significant health disparities in comparison to their urban and suburban counterparts and are also less likely to be included

COVID-19 research and clinical trials throughout UC Davis have a quiet and crucial backbone that is hard to describe – even for the directors of this center providing the support. The Clinical and Translational Science Center (CTSC) is one of the unsung heroes of UC Davis’s COVID-19 research while also serving as protector of ongoing clinical trials during the pandemic. “We’re the infrastructure

Georgia CTSA and Emory University including the Emory Medical Laboratory assisted the Centers for Disease Control and Prevention (CDC) and the Federal Emergency Management Agency (FEMA) in conducting a serosurvey to assess the presence of antibodies to SARS-CoV-2 among their workforce who are participating in the COVID-19 response. Georgia CTSA completed more than 1,200 blood draws for a COVID-19

Are two drugs better than one when it comes to treating B-cell acute lymphoblastic leukemia? Funding from the St. Baldrick’s Foundation will help a Penn State College of Medicine investigator answer that question. Dr. Chandrika Gowda, an associate professor of pediatrics and Four Diamonds researcher, received a $75,000 St. Baldrick’s Scholar Grant to continue work on a project that is exploring

Five questions with our visiting medical student interns from around the U.S. Every year, medical school students from across the U.S. participate in a summer of clinical and translational research in Harvard labs through the Visiting Research Internship Program (VRIP), offered by the Harvard Catalyst Diversity Inclusion program. This summer, VRIP has taken on a new digital format. Hear from

Five questions with our visiting medical student interns from around the U.S Every year, medical school students from across the U.S. participate in a summer of clinical and translational research in Harvard labs through the Visiting Research Internship Program (VRIP), offered by the Harvard Catalyst Diversity Inclusion program. This summer, VRIP has taken on a new digital format. Hear from summer

An interprofessional group of professors at the Medical University of South Carolina (MUSC) and educators at the Gibbes Museum of Art in Charleston, SC are collaborating to create a safe space through art for conversations about the complex issues facing health care providers. The effort is led by Cynthia Dodds, Ph.D., associate professor in the MUSC College of Health Professions and principal

As U.S. scientists ramp up a national effort to evaluate COVID-19 vaccine candidates at clinical trial sites across the country, researchers at Washington University School of Medicine in St. Louis and the Saint Louis University Center for Vaccine Development have been tapped to join the historic effort to find a COVID-19 vaccine that can prevent the illness.

Assigning authorship and recognizing contributions to scholarly works is challenging on many levels. Here we discuss ethical, social, and technical challenges to the concept of authorship that may impede the recognition of contributions to a scholarly work. Recent work in the field of authorship shows that shifting to a more inclusive contributorship approach may address these challenges. Recent

Although cough and fever have been considered the most tell-tale signs of COVID-19, in May, researchers published a study suggesting that loss of smell and taste were better able to predict who would test positive for the disease. The insight came from data shared by millions of individuals who logged on to a phone app to report what, if any, symptoms they were experiencing on a given day. The

Viruses may be colorblind, but the more we understand COVID-19, the worse it seems to get for Black, Hispanic and Native American Minnesotans. "It really goes back to social determinants of health," says Mayo Clinic's Dr. Mark Wieland. "People from minority households and immigrant households are more likely to live in multi-generational homes, more likely to have to go to work as essential

LITTLE ROCK — A national database for patient cancer images at the University of Arkansas for Medical Sciences (UAMS) will become the storage site for COVID-19 clinical images from across the United States and around the globe, including chest x-rays and CT scans of the body. This week, UAMS also became the first research institution to contribute de-identified images of COVID-19 to the storage

Community Conversations is a special spotlight series featuring conversations with diverse members of the St. Louis regional community concerning how they are viewing the COVID pandemic, and what strategies they use to thrive in this time of uncertainty.

One of the first synergy papers supported by the CLIC and CTSA consortium was published in the Journal of Clinical and Translational Science. Abstract: A primary barrier to translation of clinical research discoveries into care delivery and population health is the lack of sustainable infrastructure bringing researchers, policymakers, practitioners, and communities together to reduce silos in

The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) has produced a series of videos emphasizing the value of engaging patients and communities in clinical research. Hear interviews with our Participant Advisory Board (PAB) members, pilot study investigators, KL2 scholars, community partners, and GHUCCTS staff on why this work matters.

The Abraham Lilienfeld Award Award Description The College's most prestigious award is given in honor of Abraham Lilienfeld, a founder of the American College of Epidemiology and a renowned teacher and scholar. The Lilienfeld Award is conferred each year at the Annual Meeting. The Lilienfeld Award recipient is invited to address Fellows and Members of the College during the Annual Meeting Award

Shortly after healthcare system M Health Fairview converted Bethesda into a COVID-19 hospital, they teamed up with the University of Minnesota CTSA. Together, the partners built a robust infrastructure for COVID-19 research, pursuing innovative ways to engage Bethesda patients in the research process and optimize the way studies are conducted.

Georgia CTSA investigators Evan Anderson, MD, and Nadine Rouphael, MD, co-authored results published in NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2022483 reporting a robust anti–SARS-CoV-2 immune response in all study participants during the investigational mRNA-1273 vaccine phase 1 trial. Anderson is the principal investigator and Rouphael is the contact principal investigator for the

As COVID-19 cases surge in South Carolina and other hot spots around the country, demand continues to grow for remdesivir, one of the only medications that has shown benefit in patients with severe disease. Unfortunately, Gilead Science, the drug's manufacturer, had limited supplies of remdesivir on hand when its benefits for patients with severe COVID-19 were first announced this spring. As a

When COVID-19 first hit Rochester, NY, a team of clinicians and researchers mobilized to bring the most promising clinical trials to their community. The COVID-19 Interventional Trials Working Group, which was assembled by the University of Rochester Clinical & Translational Science Institute (UR CTSI), coordinates coronavirus-related research across the University of Rochester Medical Center

The Clinical and Translational Science Institute’s Clinical Research Services (CRS) program at UCSF is excited to announce the FDA approval of the drug therapy Fintepla (fenfluramine) for Dravet syndrome, a severe form of pediatric epilepsy with frequent or prolonged seizures. CRS provided critical support for the drug research and trial over the past few years through its Pediatric Clinical

In case you were unable to attend the July 15, 2020 webinar, you can now watch the recording! Opening remarks by CD2H leader Chris Chute. Guest speakers included Danielle Mowery, Marylyn Ritchie & Christian Stoeckert of the University of Pennsylvania and Rohit Gupta of the University of California, San Francisco for a discussion of biospecimens and their phenotypes for data sharing.

We’re thrilled to join forces with @HHPHorg for #20SegundosOMas Together with Olajide Williams, the President and Founder of Hip Hop for Health, and faculty of the Columbia University CTSA Hub, this PSA features over 30 community influencers and activists who represent the full depth, breadth and diversity of the Latino diaspora. In just a few hours it had already reached an audience of more than

Webinar series trains aspiring clinical and translational researchers in communications, leadership, and mentoring. “There’s no denying we are in unusual times. It’s our duty as educators and facilitators to continue providing educational resources during the challenging circumstances we are facing,” said Elliott Antman, MD, who serves as the director of Harvard Catalyst’s Postgraduate Education

Clara Dutari is bilingual, interpreting for Spanish-speaking patients at VCU Health. But she doesn’t just convert words, like a Spanish-English dictionary. She provides context, nuance and intuition to improve communication. One of six interpreters and translators at VCU Medical Center, Dutari sometimes sees patients nodding as their doctor speaks, but she can tell just by looking that the

CO-ACIT: COVID-19 & DISTANCE Study UCSF Surgeon-scientist Lucy Kornblith, MD (principal investigator) and her mentee, Zachary Matthay, MD (co-principal investigator) were awarded two grants for their proposed COVID-19 related research by the UCSF COVID-19 Rapid Response Pilot Grant program supported by the National Center for Advancing Translational Sciences, National Institutes of Health

Congratulations to Jessica Shantha, MD, Assistant Professor, Section of Vitreoretinal Surgery and Diseases and Section of Uveitis and Vasculitis, Emory Eye Center, and Georgia Clinical & Translational Science Alliance (Georgia CTSA) Master in Science in Clinical Research (MSCR) trainee who is the recipient of the American Academy of Ophthalmology’s 2020 Artemis Award. This award recognizes a young

COVID-19 cases in the New York City tri-state area have reached extraordinarily high number and have quickly become an epicenter region of the crisis in the United States. In New York State alone, there are over 400,000 confirmed cases as of July 1, 2020. NYU Langone Health (NYULH) has been particularly hard hit, treating over 31,000 COVID-19 patients since March 14, 2020. The complexity of the

Summary: Stakeholder engagement can play an important role in increasing public trust and the understanding of scientific research and its impact. Frameworks for stakeholder identification exist, but these frameworks may not apply well to basic science and early stage translational research. Methods: Four Clinical and Translational Science Award (CTSA) hubs led six focus groups and two semi

To mitigate risk of COVID-19, two University of Minnesota (UMN) researchers are analyzing factors such as race, economic stability, living environment, education, and more to get a more comprehensive, holistic picture of health.

To prepare for current and future waves of COVID-19, the U.S. Army’s Telemedicine and Advanced Technology Research Center asked teams from across the country to compete to build a telehealth prototype that would provide adequate ICU capacity when cases surge. Of the 78 teams that competed, only nine were invited to complete a series of tasks designed to establish the feasibility of their

Behind-the-scenes efforts at Harvard University lead to large-scale contact tracing in Massachusetts. Contact tracing, along with testing and quarantining, is a cornerstone of infectious disease control in absence of a vaccine. Thanks in part to behind-the-scenes efforts at Harvard University, Massachusetts was first in the nation to start large-scale contact tracing of those testing positive for

Medical school students virtually participate in annual summer c/t research internship program. Our annual Visiting Research Internship Program has embarked on a new virtual format. Every year, medical school students from across the U.S. come to Boston for a summer of clinical and translational research in Harvard labs through the Visiting Research Internship Program (VRIP), offered by the

The Duke CTSA KL2 program was recently identified as one of the top program hubs by the Center for Leading Innovation and Collaboration (CLIC). The Duke KL2 program was a top performer in the KL2 education program – Underrepresented measure. The CLIC evaluates programs using a Common Metrics Initiative. In alignment with the CLIC’s current goals, the Duke KL2 program set a goal to increase the

Six months into the pandemic, people diagnosed with mild cases of COVID-19 still are told to isolate themselves and wait out the infection at home. Doctors monitor such patients so they can intervene if their condition deteriorates, but no antiviral drugs have been shown to hasten recovery or forestall severe illness in people who are not sick enough to be hospitalized. Consequently, the hunt is

In collaboration with The Foundation for Barnes-Jewish Hospital (FBJH), the Washington University Institute of Clinical and Translational Sciences (ICTS) awards 11 investigators as part of the COVID-19 Research Funding Program. These eight-month grants provide critical financial support for COVID-19 translational research with potential direct clinical impact within the next 12 months. All

Back in mid-March at the forefront of the pandemic shutdown, Washington University School of Medicine neurologist and ICTS investigator Eric Landsness, MD, PhD, was immediately thinking about how he could help. “As an academic neurologist, I wasn’t on the front lines,” commented Landsness. “But it was personally important to me to find a way that I could contribute to the efforts and help COVID

With Brazil leading the world in newly diagnosed COVID-19 cases, Latin America has become the epicenter of the coronavirus pandemic. Meanwhile, outbreaks continue to escalate in parts of Asia, Africa and the Middle East. Public health authorities worldwide desperately need to expand testing so they can track the spread of the infection, but molecular diagnostic tests used in the U.S. and other

Pennsylvania could benefit from implementing statewide guidelines for defining patient navigation and specifying the roles and responsibilities of patient navigators, according to Penn State College of Medicine researchers. Patient navigation programs guide cancer patients through the healthcare system. The programs feature patient navigators who help cancer patients access and manage their

The R-Writing Group at the North Carolina Translational and Clinical Sciences Institute assists participants in developing their first, competitive, investigator-initiated research grant application to NIH or R-equivalent grant to another funding agency for submission in June 2021. This program is open to new investigators and investigators who have submitted an R-type grant before, as long as

At first, there were only questions. When the COVID-19 pandemic hit, the only thing known about the virus was how little was known about it. But while VCU Health doctors and nurses focus on saving lives and finding treatment options, other Virginia Commonwealth University researchers behind the scenes are setting the stage for long-term investigations into the novel coronavirus. Somaya Albhaisi, M

With the onset of the COVID-19 pandemic, the National COVID Cohort Collaborative (N3C) was rapidly assembled to answer questions and meet emerging research needs brought to light by the novel coronavirus. In the span of two months, the N3C developed work groups to address governance issues, as well as issues concerning data partnerships and acquisition, data harmonization, and the creation of a

Penn State’s Sexual Assault Forensic Examination Telehealth (SAFE-T) Center has been utilizing telehealth along with a community-engaged solution to enhance sexual assault care in rural and underserved communities in Pennsylvania. Now, its researchers are providing a guide to help others interested in creating similar programs. According to experts, nearly 1 in 3 women and 1 in 4 men experience

The University of Illinois at Chicago Center for Clinical and Translational Science has released a free online version of its popular human research protection training program for community partners, CIRTification.

Since COVID-19’s spread to the United States earlier this year, death rates in the U.S. have risen significantly. But deaths attributed to COVID-19 only account for about two-thirds of the increase in March and April, according to a study published Wednesday in the Journal of the American Medical Association. Researchers at Virginia Commonwealth University and Yale University found that, from

When the COVID-19 pandemic hit U.S. soil, Jessica Burris, a first-year medical resident at Yale, was told to stay home. Although most cases of COVID-19 were mild, the disease could turn severe or fatal for people at high risk, such as the elderly or those with pre-existing conditions or compromised immune systems. Burris, who takes immunosuppressants to control her inflammatory bowel disease (IBD)

Michael Kappelman, MD, MPH, a professor in the division of pediatric gastroenterology in the Department of Pediatrics, has been recognized by the Crohn’s & Colitis Foundation as a recipient of the 2020 Uniting to Care & Cure Award. The award recognizes members of the IBD professional community who go above and beyond to support the Foundation’s mission to improve patient quality of life and find

The Wright Center is co-hosting a series of virtual town halls with Virginia State University this summer, bringing Virginia Commonwealth University physician-scientists to undergraduate students interested in pursuing careers in medicine and research. Robert Winn, M.D., director of VCU Massey Cancer Center and a Wright Center faculty member, kicked things off on Friday, speaking to a group of 15

People’s expectations for compensation and control may increase as they become more aware of privacy concerns and the ways in which genomic database companies are profiting from their data, according to researchers at Penn State and Cornell University. This research was partially supported by Penn State Clinical and Translational Science Institute through support of Jennifer McCormick, ethics lead

LITTLE ROCK — The University of Arkansas for Medical Sciences (UAMS) has developed and begun using high-accuracy antibody testing to determine the magnitude of COVID-19 infection in Arkansas and inform the decisions of policymakers. As part of the research program, UAMS will collect blood samples from nearly 7,500 Arkansas adults and children through October. By early August, a robotic-assisted

The Georgia CTSA Evaluation and Continuous Improvement (ECI) program recently completed a study providing greater insight into the range and depth of short-term influence and long-term impact made by a portfolio of 250 Georgia CTSA-supported pediatric publications. This evaluation of Georgia CTSA’s pediatric research output found a body of work that is highly impactful compared to similar work by

Given how recent and unknown the Coronavirus disease is, and its inherent epidemic nature, there are a limited number of cases at individual medical institutions. The limitation of the number of cases per institution becomes even more relevant when isolating subpopulations with specific health conditions and across the lifespan. COMBATCOVID will bring together electronic health records (EHR) data

Since its launch in 2017, the Clinical and Translational Science Institute’s Sample Size calculator website (sample-size.net) has gained traction not only at UCSF, but nationwide – it had 300,000 sessions in the past year with users from 1,200+ universities. It is the standard site used for UCSF courses, including Designing Clinical Research and the undergraduate medical education courses on

TUCSON, Ariz., June 23, 2020 — As millions of patients struggle with diseases that lack adequate treatments, there is a critical need to understand how existing drugs can be used in new ways to improve clinical outcomes. Health care professionals use drugs in novel ways as a potential life-saving intervention when no specific approved therapies are available. However, without the ability to share

As MUSC Health leaders began to plan for the onslaught of COVID-19, they thought that Charleston would see the highest increases in hospitalizations in South Carolina. Instead, some of MUSC Health’s regional hospitals, acquired just over 15 months ago, have been the hardest hit. MUSC Health Florence Medical Center, for example, has one-fourth the patient census of MUSC Health Charleston but four

OCTRI announces six awardees to two tracks of the Biomedical Innovation Program: COVID-19 Rapid Response and Digital Health.

As more health care providers adapt to telehealth to care for patients during the COVID-19 pandemic, some are finding occasional challenges with the experience when it’s new to them. Now, some help is available in a new set of how-to videos for health care providers from UC Davis pediatric endocrinologist Stephanie Crossen. Crossen shares her expertise alongside Jennifer Raymond, pediatric

The National Institutes of Health has launched a centralized, secure enclave to store and study vast amounts of medical record data from people diagnosed with coronavirus disease across the country. It is part of an effort, called the National COVID Cohort Collaborative (N3C), to help scientists analyze these data to understand the disease and develop treatments. This effort aims to transform

Local innovators and members of the Minnesota entrepreneurial community gathered May 15, 2020, for a virtual Walleye Tank: COVID-19 Showcase. The event showcased how Minnesota innovators and community leaders are stepping up to conquer COVID-19 challenges. It was hosted by Mayo Clinic Office of Entrepreneurship and University of Minnesota. The event is typically held as an in-person pitch

Our Community Engagement faculty lead discusses the importance of community engagement in the era of COVID-19 and her focus on implementation science Karen Emmons, PhD, is faculty lead of our Community Engagement program and professor of social and behavioral sciences at the Harvard T.H. Chan School of Public Health (HSPH). What lessons does the coronavirus crisis offer about the importance of

The recent deaths of George Floyd, Ahmaud Arbery, and Breonna Taylor, in addition to the disproportionate burden of COVID-19 on African Americans, are wrenching reminders of the many harms that societal racism, inequality, and injustice inflict on the Black community. These injustices are rooted in centuries of oppression—including slavery and Jim Crow, redlining, school segregation, and mass

The Clinical and Translational Science Institute’s (CTSI) Community Engagement and Health Policy program (CEHP) is proud to announce that its UCSF COVID Patient and Community Advisory Board (PCAB) has been funded by the Patient-Centered Outcomes Research Institute (PCORI). The COVID PCAB was created to provide an easily accessible and efficient mechanism to help UCSF researchers obtain patient and

With funding from the Harry T. Mangurian Jr. Foundation, the University of Rochester CTSI has partnered with the University of Rochester Medical Center to provide its researchers with a new and powerful tool in understanding the diagnosis and progression of coronavirus. The team has developed a COVID-19 Biobank that will safely collect and store blood samples from COVID-19 patients and link the

The CTSA program provides opportunities for hub members to come together and advance knowledge and progress around various topics. One way this is accomplished is through working groups. Working groups consider and develop solutions around a specific clinical and translational science issue and provide deliverables that fill identified translational gaps. Ana Baumann, PhD, Research Assistant

In the weeks before the St. Louis region saw its first patients with COVID-19, physician-scientists at Washington University School of Medicine began planning and preparing how best to collect blood and other biological samples from such patients so specimens could be quickly disseminated to researchers seeking strategies to treat, prevent and contain the novel coronavirus. With financial support

The Wright Center has led a committee that evaluates and activates COVID-19 drug treatment trials, three more of which were activated recently. Armed with years of research experience and the reputation of VCU as a research institution, physician-scientists recently launched three new studies. Initiated by a trauma surgeon, a liver specialist and a pulmonologist, the new trials speak to the

There has been a growing need for patient records to be readily available, discoverable, and understandable. To address this need, Health Level 7 (HL7) International, a standards developing organization, developed the Fast Healthcare Interoperability Resources (FHIR) standard to facilitate electronic exchange of healthcare information across organizations. HL7 has initiated the FHIR Accelerator

Ida Sim, MD, PhD, co-director of the Informatics and Research Innovation (IRI) program at CTSI and professor of Medicine, shares insights on the CommonHealth project and app. CTSI provided funding support to pilot the app at UCSF. CommonHealth is an Android app similar in function to Apple Health. It is designed to make it easy for people to securely collect their electronic health record data and

In the midst of a pandemic, human health research has never been more important. Now graduates can prepare for a career in it at Virginia Commonwealth University. The C. Kenneth and Dianne Wright Center for Clinical and Translational Research, VCU’s home for science that supports the health of the community, will enroll its first class of students this fall in a new post-baccalaureate Certificate

A team of Penn State researchers developed a first-of-its-kind clinical trial to test the use of exercise as a treatment for patients with a severe form of nonalcoholic fatty liver disease. Nonalcoholic fatty liver disease is the leading cause of chronic liver disease in the United States. People with this disease have an extra fat build up in their liver cells not caused by drinking alcohol. It

An investigator at the University of Michigan is part of a multi-site study that is evaluating whether continuing medication versus discontinuing common blood pressure medications (ACE inhibitors or angiotensin receptor blockers) at time of hospitalization for COVID-19 makes a difference in how people recover and respond to treatment, focusing on two of the most common blood pressure treatments in the U.S.

CU Anschutz and CCTSI play a key role in developing antiviral medications and working to attenuate the inflammatory response. In just a few months, physicians have developed key findings through multiple clinical trials at CU Anschutz, testing previously FDA-approved drugs and new medications to battle COVID-19. “Two months ago I would not have guessed we’d have encouraging results so quickly,”

Georg Gerber, MD, PhD, MPH, is chief of Brigham and Women’s Division of Computational Pathology and HMS associate professor of pathology. A microbiome computational biologist, his project, “Predicting C. difficile recurrence from the microbiome using interpretable machine learning models,” received pilot funding through our Translational Innovator program. His nonlinear career path began with

Maurizio Fava, MD, is an associate dean for clinical and translational research at Harvard Catalyst, Harvard Medical School Slater Family Professor of Psychiatry, and psychiatrist-in-chief at the Massachusetts General Hospital, where he is also director of the Mass General Research Institute and executive director of the Clinical Trials Network and Institute. Is your department doing virtual

David Alejandro Sanchez, MD, is a resident in internal medicine at Brigham and Women’s Hospital (BWH). He was one of our visiting medical students from the summer of 2014 in the Visiting Research Internship Program (VRIP), mentored in the laboratory of Raymond Huang, MD, PhD, at BWH. How influential was your VRIP experience? My summer as a VRIP intern was my first real introduction to clinical

As part of an effort to reach out to investigators and bench scientists looking to get into translational science, the North Carolina Translational and Clinical Sciences (NC TraCS) Institute has recently released a video serving as an overview of their services. This video explains the importance of translational science and how our institute has been able to move forward the research agenda. It

Since MICHR was awarded the Transforming Expanded Access to Maximize Support and Study (TEAMSS) grant two years ago, the consortium of universities involved in TEAMSS has worked to develop and test infrastructure, best practices, and reduce burdensome data collection for expanded access that will allow other academic medical centers to become more effective and efficient in supporting these requests.

UMHealthResearch.org (UMHR) is designed to go above and beyond a typical participant recruitment platform because it allows for study use both ways: volunteers (both healthy and with specific medical conditions) and researchers can search for studies and find matches based on their interests and needs. This unique participant recruitment site has received national recognition and attention across the Clinical and Translational Science Award (CTSA) consortium. UMHealthResearch is now being deployed across the country at half a dozen other CTSA programs in Illinois and Florida, with more expressing interest as the word spreads about its unique design and interface.

With Michigan communities facing devastating impacts from the COVID-19 pandemic, the Community Engagement (CE) program at MICHR focused its efforts on assessing and addressing the needs of its community partners. This resulted in a digital toolkit that acts as a landing page for its numerous services and resources. Simply scroll through to learn more: https://michr.umich.edu/resources/2020/4/21

“Classes relatively seamlessly have transitioned to an online platform.” “Online classes are equally good. Instructors have adapted.” “Clear communication about changes.” “Everyone has been very flexible.” These are comments from Georgia CTSA students who transitioned to online learning. Halfway through the Spring 2020 semester, the Georgia Clinical & Translational Science Alliance (Georgia CTSA)

By Leslie Lawler June 4, 2020 “This is an extraordinary, inspiring time; Massachusetts has a huge depth of understanding in biomedical and clinical research,” said Robert Sege, MD, PhD, co-director of community stakeholder engagement at Tufts Clinical and Translational Science Institute (CTSI). “Many of our scientists and investigators have turned from their own academic interests to research that

A University of Minnesota researcher is co-leading an effort to test wastewater across Minnesota. This would help scientists and public health officials see how prevalent COVID-19 is in a given community and understand where the virus is spiking or trending downward.

If there is one thing the coronavirus pandemic has made clear, it's the necessity of translating, as quickly as possible, the discoveries made in medical laboratories into actual treatments, procedures and diagnostic tools that can help patients. Frontiers: University of Kansas Clinical and Translational Science Institute has awarded three one-year $50,000 pilot grants to help scientists studying

Mario Castro, MD, MPH, has been named the Principal Investigator and Director of Frontiers: University of Kansas Clinical and Translational Science Institute, effective June 1, 2020. In this role, Castro will lead, manage and shape the strategic direction of the clinical and translational research enterprise throughout the Kansas City region and across the state. "As a clinical translational

Pennsylvania adolescents and young adults are less likely to receive cancer treatment at a specialized treatment center than pediatric patients, according to a team of Penn State and Penn State Cancer Institute researchers. Specialized centers provide access to clinical trials, psychological and social support services and other medical approaches. These are all critical to the comprehensive care

NCATS is an integrator, bringing together diverse people, technologies, and information to produce insights and advances that no one could do alone. This modus operandi is never more important than in an urgent public health crisis like the COVID-19 pandemic, when data often are limited, and the scientific and medical situation is changing rapidly. One key to data integration is having the tools

Two of Georgia CTSA’s leaders head up the NIBIB-funded Atlanta Center Microsystems Engineered Point of Care Technologies (ACME POCT) which has been selected by the NIH, along with their institutions - Emory, Georgia Tech, and Children’s Healthcare of Atlanta - to test and validate some of the most promising technologies for COVID-19 diagnostic testing. Wilbur Lam, MD, PhD is the Principal

Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing cells and used the gene-editing tool CRISPR-Cas9 to correct a genetic defect that had caused the syndrome. They then implanted the cells into lab mice and cured the unrelenting

Thank you to the National COVID Cohort Collaborative (N3C) for your outstanding efforts! See the latest press release from Oregon Health & Science University.

As the COVID-19 pandemic takes more lives each day across the U.S., public health officials report that racial and ethnic minorities are disproportionately impacted. In a paper published as an accepted pre-proof article May 15, 2020, in the Journal of Clinical and Translational Science, researchers at Mayo Clinic detail how a community-engaged intervention tackled critical health communication

"A potentially fatal inflammatory response that occurs in some people with COVID-19 infections may be alleviated with a medication that's being assessed in a study at Virginia Commonwealth University." Wright Center researchers Antonio Abbate and Benjamin Van Tassell are featured in a Richmond magazine story about the dangerous inflammatory response in patients with COVID-19. "Abbate is a

A New Focus Even though we as a group are introverted scientists, I think we are learning how much of our routine is predicated on social interaction. We are always talking with colleagues and walking over to the next lab for a piece of advice or to borrow some trivial reagent. It’s so important to be able to think out loud or ask a colleague about some detail. This is all much more difficult

Kathy White enrolled in the sarilumab trial at VCU, one of several active clinical trials for COVID-19 patients. Joining a clinical trial, she said, gave her purpose. “I just felt like, that's the least I could do to contribute to cleaning up this mess.”

High levels of social distancing would lower the COVID-19 infection, hospitalization and death rates over the next six months across all counties in Missouri, finds a new study from Washington University in St. Louis. Although death rates will be lower than in urban areas due to lower population density, rural areas will see significant numbers of hospitalizations and deaths from COVID-19. In all

Emergency departments may play a surprising role in the reduction of readmission rates following the implementation of Medicare’s Hospital Readmissions Reduction Program, according to a recent analysis. Charleen Hsuan, assistant professor of health policy and administration at Penn State, led a study that examined what happens to discharged patients when they returned to a hospital’s emergency

Among prostate cancer cases, highly aggressive cases of the disease at the time of diagnosis increased significantly in Pennsylvania between 2004 and 2014, according to Penn State College of Medicine and Penn State Cancer Institute researchers. The increase affected both white and black men, with black men having more highly aggressive prostate cancer at diagnosis. This rise could be because of

More than 400 randomized clinical trials (RCTs) have been registered on clinicaltrials.gov, many are meant to answer similar questions but lack any method to combine data and evidence. By aggregating evidence across these trials, we can learn about interventions for COVID-19 as quickly and reliably as possible. The COVID-19 Collaboration Platform brings disparate research teams working on the same

“The Georgia CTSA is an incredible group of colleagues to build together. My experience in the Georgia CTSA KL2 Program is just one example of how an investigator is being supported by this talented team of people and comprehensive resources to make exciting advances and produce outstanding work,” says Dr. Joshua Levy. Joshua M. Levy, MD, MPH, Emory Sinus, Nasal & Allergy Center; Assistant

Eleven Virginia Commonwealth University faculty members are among the final researchers to receive internal funding to pivot their work to address the impact of the COVID-19 pandemic on the health system and the community. They were among the nearly 70 investigators who applied for support through the VCU COVID-19 Rapid Research Funding Opportunity, sponsored by the Office of the Vice President

The COVID-19 pandemic raises many difficult questions for clinicians, researchers and informaticians. Which drugs are the most viable candidates for a given patient? How can we efficiently and effectively assemble the right cohort for a trial? What social determinants impact course and outcome? How can we rapidly deploy clinical decision support tools when new knowledge is available every day? The

Planning for your first R01 application can be daunting. Even for seasoned investigators, it takes time and requires sufficient preparation. Early-stage investigators can find needed support by utilizing resources from the ICTS throughout their grant submission process. Recently funded by the National Institute on Aging with the National Institutes of Health (NIH), ICTS members, Sarah Hartz, MD

Researchers at the University of Wisconsin Institute for Clinical and Translational Research (UW ICTR) recently launched a Neighborhood Health Partnerships (NHP) website (https://nhp.wisc.edu/) that provides ZIP code level data for Wisconsin counties to estimate number and prevalence of individuals who may be at risk of developing severe complications from COVID-19. This information can be used by

Someday, hundreds of millions of vaccinations against the coronavirus that causes COVID-19 could show up in people’s mailboxes and be applied as simply as slapping on a Band-Aid. That’s the vision of Wright Center KL2 Scholar Guizhi “Julian” Zhu, Ph.D., at the Virginia Commonwealth University School of Pharmacy. Zhu’s research was one of the first 20 proposals to receive grants from the VCU COVID

Penn State College of Nursing’s SAFE-T Center team, led by assistant professor and center director Sheridan Miyamoto, is working to address barriers to health care for rural sexual-assault victims with their new telehealth solution, the SAFE-T System. According to the center, there are more than 284,000 victims of sexual assault across America every year. Victims require timely, skilled, and

The Office of the Vice President for Research and Innovation and the Wright Center are foregoing certain typical licensing fees during the pandemic in order to facilitate the research and development that will help combat COVID-19 collaboratively. In addition to ensuring access to new technologies, VCU has made available its standard operating procedures for research teams, including inventors and

Doctors and researchers are faced with innumerable questions about the novel coronavirus. As a novel, or new, virus to humans, SARS-CoV-2 is still mysterious. How exactly is it attacking? Why do some people get mild, barely noticeable cases while other previously healthy people end up intubated in intensive care units? How does the immune system respond to this virus, and how does it exacerbate

William Powderly, MD, ICTS Director, speaks on how Washington University School of Medicine physicians prepped for COVID-19 in a recent article in The Record, the official newsletter of Washington University in St. Louis. "The creativity, flexibility and dedication our health care providers have shown in the face of this novel and sometimes deadly virus has been extraordinary, " said Powderly.

FastTraCS is a small group of biomedical engineers at the North Carolina Translational and Clinical Sciences Institute who support UNC Health physicians, nurses and staff by identifying problems in clinical settings and creating innovative, technological solutions. In this special series, we cover how the team is responding to the ongoing COVID-19 crisis. Like millions of people across the country

“What we have learned about inflammation for HIV is a foundation for streamlined effective approaches towards other diseases and viral infections including COVID,” says Dr. Christina Gavegnano. Christina Gavegnano, PhD, Assistant Professor, Emory University School of Medicine, and Georgia Clinical & Translational Science Alliance (Georgia CTSA) Certificate Program in Translational Research (CPTR)

The community-academic partnership between Saint Louis University researcher Pamela Xaverius, PhD, MBA, Associate Professor of Epidemiology, Saint Louis University College for Public Health and Social Justice and Rose Anderson-Rice, Deputy Director with Generate Health, is utilizing ICTS funding to meet the needs of mothers and families living in government housing during the current COVID-19

New findings from the Established Status Epilepticus Treatment Trial (ESETT) were released on March 20, 2020 in The Lancet that validate the use of three drugs and give acute care healthcare providers options when it comes to treating patients with refractory status epilepticus across all age groups. The Cincinnati CTSA, Center for Clinical and Translational Science and Training (CCTST) Acute Care

New U-M Network-Based Research Unit Connects Researchers The COVID-19 pandemic has suddenly hit the world with a virus that we know almost nothing about. We don’t have a good understanding of how the virus affects people of different ages, races, medical conditions, etc. Many states are reporting only the most basic information, such as the number of deaths. The Network-Based Research Unit (NBRU) at the University of Michigan's Michigan Institute for Clinical & Health Research (MICHR), working together with several regional and national research networks, has pivoted to work collaboratively on the Coronavirus pandemic by making COVID-19 patient data available to researchers.

The University of Michigan's Center for Drug Repurposing (UM-CDR) is taking on the challenge of finding a drug previously approved by the FDA – or more likely a cocktail of several drugs – to battle COVID-19, the illness caused by the novel coronavirus. Assisted by artificial intelligence methods, the U-M team will begin screening all 2,400 FDA approved drugs and will extend screening to experimental compounds from a library of nearly 7,000 compounds in search of an antiviral drug or drug cocktail that is effective against COVID-19.

Study Addresses Effectiveness of HCQ on Healthcare Providers The University of Michigan was selected to participate in the first study to use the new national HERO registry. Led locally by Marisa Miceli, MD, and Peter Higgins, MD, PhD, MSc, this study focuses on how effective Hydroxychloroquine (HCQ) may be in protecting healthcare providers. “The multi-site study will be large enough to definitively address questions such as ‘Can HCQ prevent COVID infections in Health Care Providers (HCP)? Or “Can HCQ reduce the severity of COVID infections in HCP?” said David Williams, PhD, Professor of Anesthesiology, and faculty lead of the Michigan Institute for Clinical & Health Research 's (MICHR’s) new Network-Based Research Unit (NBRU). In supporting this first study, MICHR is facilitating rapid regulatory approval, contracting, and budgets, with the help of the Ambulatory and Chronic Disease Clinical Trial Support Unit.

To aid accessibility to crucial COVID-19 patient data, the Michigan Institute for Clinical & Health Research (MICHR) at the University of Michigan (U-M) launched a COVID-19 Rapid Response Research Registry to offer a centralized clinical characterization and management resource of what the scientific and health care community has learned through this public health pandemic. With the launch of a

Virginia Commonwealth University has become one of the first sites in the world to begin clinical trials to study the safety and efficacy of the drug canakinumab on patients experiencing a type of severe immune overreaction called cytokine release syndrome, which occurs in some patients with pneumonia due to COVID-19. “When you have heart disease, the [disease] triggers inflammation, and the

The Clinical and Translational Science Institute (CTSI) at UC San Francisco (UCSF), a unit within the Office of Research, will support, coordinate and respond to COVID-19 research needs. Some of CTSI’s efforts to support impactful COVID-19 research include: Pilot Awards The UCSF COVID-19 Rapid Response Pilot (C19 RRP) Grant Program, co-sponsored by the Academic Senate, CTSI’s Pilot Program, and

The story below, released by Cincinnati XVXU, features Cincinnati CTSA K Scholar Graduate, Carley Riley, MD, MPP, MHS, FAAP. Food for the hungry is now within walking distance for hundreds more Cincinnatians after a team of problem solvers used data analytics to strategically place food distribution centers closer to them. As part of The Kroger Co.'s Zero Hunger/Zero Waste initiative, the city of

Few would describe the pace of academic medical research as swift. Yet last month, the CCTSI disrupted its own processes and timelines by issuing a new rapid-release RFA to address COVID-19. The CCTSI COVID-19-Related Research Pilot Program – or C2R2 – supports the development of novel diagnostic and treatment methods and innovative technologies related to the COVID-19 outbreak.

The Ohio State University’s Office of Research announced details of the final round of funding to boost research in response to the COVID-19 pandemic. Eleven additional projects were awarded funding for a total of $310,000. Through three rounds of funding, 24 projects were awarded over $770,000 from the Office of Research.

[BOSTON, Mass. – May 5, 2020] Leaders from Tufts Clinical and Translational Science Institute (CTSI) announced two research projects related to COVID-19 that were selected to receive $25,000 each in pilot studies grant funding: • Targeting Tumor Necrosis Factor (TNF)-α as a Central Driver of the Cytokine Storm in Lethal Coronavirus Disease 2019 (COVID-19), led by Paul Mathew, MD of Tufts Medical

Arun Sanyal is practicing science but offering hope. He’s a gastroenterologist, a liver specialist and an internal medicine professor at Virginia Commonwealth University’s medical school, as well as a researcher with the VCU Massey Cancer Center. Emergency medicine is not his specialty, but Sanyal is playing a critical role in the COVID-19 pandemic, serving as principal investigator in trials of a

“One of the things we will take away from this pandemic is the enhanced focus on infection prevention – washing our hands, not touching our face, and not going to work when we're sick. All of those things should always be practiced,” says Dr. Marybeth Sexton. Marybeth Sexton, MD, MSc, Assistant Professor, Emory University School of Medicine, member of the Serious Communicable Disease Unit team at

“The way we advance medicine is through clinical research,” says Wright Center Director F. Gerard Moeller, M.D., in a story about how patients and healthy volunteers can join clinical trials and research projects. The Richmond Magazine article links to the Wright Center's Study Finder at studyfinder.cctr.vcu.edu.

A project to better understand virus-host interaction through the creation of a COVID-19 BioBank and another exploring the effect of COVID-19 on individuals with serious pneumonia have received rapid-response funding from the Northwestern University Clinical and Translational Sciences (NUCATS) Institute and Feinberg School of Medicine Office for Research. The successful grant applications were

Twenty Virginia Commonwealth University faculty members received internal awards to quickly pivot or expand their work to address the impact of the COVID-19 pandemic on the health system and the community. "When the funding opportunity was announced on April 3, VCU researchers across both campuses were ready to hit the ground running to address COVID-19," said F. Gerard Moeller, M.D., director of

Virginia Commonwealth University researchers have joined a growing study to test a drug developed to treat rheumatoid arthritis on patients who are critically ill with symptoms of the novel coronavirus, COVID-19. Sarilumab works to block interleukin-6, which signals the body’s immune system to create the excess inflammation seen in sufferers of rheumatoid arthritis. Doctors hope it will do the

REGISTRATION IS NOW OPEN! The rapid rise of COVID-19 has challenged healthcare globally. The underlying risks and outcomes of infection are still incompletely characterized even as the world surpasses 1 million infections. Due to the importance and emergent need for better understanding of the condition and the development of patient-specific clinical risk scores and early warning tools, CD2H has

The JUNTOS Center for Advancing Latino Health at KU Medical Center, whose mission is to eliminate health disparities in under-served Latino communities in Kansas, has been working hard to deliver COVID-19 information to Kansas City's Spanish-speaking communities in their native language. In the Kansas City area, nearly 6% of the population speak Spanish as their primary language. In Wyandotte

The North Carolina Translational and Clinical Sciences (NC TraCS) Institute is well positioned to support and accelerate promising coronavirus and COVID-19 research. This positioning is underscored by Microsoft Academic ranking of the University of North Carolina at Chapel Hill as #3 in the United States in volume of published coronavirus research, behind only the CDC and the NIH. UNC-Chapel Hill

The emergence of SARS-Cov-2, the virus behind the COVID-19 pandemic, has reminded us how important it is to speed research breakthroughs into clinical practice. Testing potential new tests and therapies for COVID-19 in clinical trials ensures that only those that are effective and safe make it to the clinic. But how can the pace of those trials be sped up? And how does one conduct such trials

For the doctors treating the hundreds of patients who are hospitalized for COVID-19 in Virginia, there’s no playbook. The disease that has spread rapidly across the world — killing hundreds in the state and more than 200,000 worldwide — has no known treatment, so COVID-19 has presented a unique challenge to the doctors faced with saving lives against a mostly unknown enemy. But in an effort to

Two Emergency Medicine faculty researchers at Oregon Health and Science University are looking for healthcare workers to take their research survey on the impact of COVID-19 on the healthcare workforce. This is a CTSA-supported study. See below. Are you a healthcare worker that comes in contact with patients? Concerned about COVID-19’s impact on the healthcare workforce? Participate in an

After months of fierce opposition, the electronic health record company Epic said Thursday it is dropping its opposition to a federal rule designed to improve patients’ access to their medical records, removing a potential barrier to its implementation.

Uriel Kim , an MD-PhD candidate in the CWRU School of Medicine Clinical Translational Science Training Program (CTSTP) and CTSC TL1 Scholar has been named the winner of the highly competitive 2020 "Outstanding Trainee: Predoctoral Scholar Award" by the Association for Clinical and Translational Science. Uriel's award includes an honorarium and his highlight video will be featured as part of the

The NIH renewed the Adolescent Brain Cognitive Development Study last week for the next seven years, and nearly $11 million of that funding will go to VCU. The young participants undergo undergo neuroimaging of brain structure and function at the Wright Center's Collaborative Advanced Research Imaging center. The center has the university's only research-dedicated MRI. VCU is one of four study

CTSA members are helping drive new research and clinical opportunities in ultra-high field magnetic resonance imaging (UHF MRI), evidenced by a November conference on the topic for the national CTSA community hosted by the University of Minnesota.

As researchers around the world race to respond to the COVID-19 pandemic, University of Rochester CTSI Co-Director Martin Zand, M.D., Ph.D., is rapidly adapting previous research to develop a potential diagnostic test that would require just a few drops of blood to detect the fast-spreading disease. The current research was born out of a past UR CTSI pilot project in which Zand’s lab created a

Diana Miglioretti, dean’s professor and division chief of biostatistics in the department of Public Health Sciences, has won the prestigious Distinguished Investigator Award from the Association of Clinical and Translational Science (ACTS). Dr. Diana Miglioretti recognized for her research on breast cancer screening. The UC Davis School of Medicine nominated Miglioretti for the Distinguished

Marcus Deloney, a trainee in the UC Davis TL1 training program, was selected at one of the six presenters at the recent Association for Clinical and Translational Science (ACTS) virtual meeting. With over 500 abstracts submitted, selection for presentation represents the top 1%. His research focuses on the use of biologically derived therapeutics to prevent the progression of osteoarthritis. These

“I am proud of our ICU teams in how they've provided excellent clinical care to COVID-19 patients during these challenging times,” says Dr. Sara Auld. Sara Auld, MD, MSc, Assistant Professor, Emory University School of Medicine and Rollins School of Public Health, and Georgia Clinical & Translational Science Alliance (Georgia CTSA) Master in Science in Clinical Research (MSCR) graduate, has helped

Jason Purnell, of the Brown School at Washington University in St. Louis, will lead a response team of over 40 St. Louis area nonprofits, social service agencies and governments to deal with the coronavirus pandemic. The COVID-19 Regional Response team aims to help people navigate resources and get help with needs including employment, food, housing, child care and legal aid. Purnell, associate

When Betsy McFarland, MD began her infectious disease fellowship at Children’s Hospital Colorado in 1992, she treated children in the hospital who were living with HIV. The experience was pivotal. “You see a child that is suffering, and you think ‘what can we do better?’” says Dr. McFarland. “To be able to participate in research that will make that child’s life better or some other child’s life

Introduction: Informed consent for research biospecimen donations is traditionally obtained through a face-to-face interaction with research staff and by signing an Institutional Review Board (IRB)-approved printed form. Electronic signatures (eSign) are routinely used in the electronic medical record (EMR) for the consenting of clinical services after patients review printed documentation. Our

CCTSI researchers play a vital role in new treatment expected to significantly improve quality of life and add years of life to those living with cystic fibrosis. Earlier this fall, the FDA approved a new breakthrough therapy for cystic fibrosis (CF), a genetic disease that leads to lung, digestive, endocrine and nutritional problems. Researchers from Children’s Hospital Colorado were part of a

The University of Rochester Medical Center (URMC) is launching a new study to understand how the body’s immune system responds to COVID-19, including if and when a person could be re-infected with the virus and whether some people have pre-existing immunity. The findings could have significant implications for the public health response to the pandemic, the development of COVID-19 vaccines, and

Doctors and nurses—many of whom are also researchers—are working around the clock at UCHealth University of Colorado Hospital (UCH) to treat patients who are hospitalized with COVID-19. Over the next several months, research teams and caregivers will treat patients using four different drugs in the course of multiple clinical trials using Sarilumab, Remdesivir and Hydroxychloroquine. The Colorado

Stephen L. Kates, the Wright Center's lead on research capacity, helped develop a sterilization pilot program to safely decontaminate N95 masks for VCU Health employees. “We have to preserve what we have. The ideal thing would be to give every nurse and doctor and technician a brand-new 3M mask every day. But given these unprecedented times, we can’t do that right now.”

The North Carolina Translational and Clinical Sciences (NC TraCS) Institute, the integrated hub of the CTSA at the University of North Carolina at Chapel Hill special call seeks to support translational research in addressing the COVID-19 epidemic. NC TraCS contribution will be up to $25K. Proposals with additional funds may have larger budgets and their scope can enhance reviewer enthusiasm

“When we first started identifying people under investigation for COVID-19, the testing was sent to the state lab with turnaround time between 3 and 4 days. By running diagnostic tests now in-house, we’ve significantly reduced the turnaround time to 6–8 hours, and under 70 minutes for special populations. That’s a huge gamechanger,” says Dr. Paulina Rebolledo. (pictured center) Paulina Rebolledo

Infectious diseases physicians at Washington University School of Medicine in St. Louis have developed an expanded access program to give blood plasma from COVID-19 survivors to critically ill patients at Barnes-Jewish Hospital in St. Louis. Led by principal investigator Rachel Presti, MD, PhD, an associate professor of medicine, a team of researchers began enrolling potential donors last week

A curated list of research resources around guidelines, policies, and procedures related to COVID-19, drawn from Harvard University's schools and affiliate institutions.

Before Arkansas had its first COVID-19 case, the reality of the impending pandemic was already setting in for UAMS faculty as cancellations for scientific conferences worldwide were announced one after another like falling dominos. For scientists and academics, presenting to their peers at conferences is one of the main ways other than publications that they share their latest findings, learn

CD2H and NCATS has recently launched the National COVID Cohort Collaborative (N3C) to address the many difficult questions raised by the COVID-19 global emergency, such as: who is infectious, who may need hospital care and at what level, what are the key risk factors, what are the best prognostic indicators, what are best practices for ethical resource allocation, and which drugs are the most

In March, someone in Seattle became the first person in the United States to take an experimental dose of a potential vaccine for the novel coronavirus, COVID-19. Doctors injected 45 healthy people as part of a clinical trial they hope will protect people from a virus that has killed tens of thousands and upended normalcy across the globe. Last month, Virginia Commonwealth University began

UC Davis Health is honored to be part of Gov. Gavin Newsom’s COVID-19 Testing Task Force, a public-private collaboration to more quickly increase coronavirus testing capacity. Nam Tran, associate clinical professor of pathology and laboratory medicine is senior director of clinical pathology and oversees COVID-19 testing at UC Davis. “UC Davis is pleased to partner with Gov. Newsom on this

FDA approves COVID-19 innovations; Ohio State Medical Center to share nationwide Interdisciplinary team of scientists develops test kit components to address shortages Eileen Scahill Ohio State News contributor eileen.scahill@osumc.edu 614-293-3737 The Food and Drug Administration has approved solutions created by scientists at The Ohio State University Wexner Medical Center that both expand and

Like doctors across the country, Benjamin Nicholson, M.D., knows the surge is coming. The emergency department doctor has seen the predictions for the spread of COVID-19 and knows a finite supply of ventilators exists across the country to support the growing number of patients experiencing respiratory symptoms of the novel coronavirus. Nicholson, who is also a clinical instructor at Virginia

The Oregon Clinical & Translational Research Institute (OCTRI) at Oregon Health & Science Universtiy (OHSU) pivoted rapidly to support our home institution and our state during this crisis. Our rapid response allowed us to become the central organizing and triage hub for clinical research during this time. This provided us the opportunity to demonstrate our value to OHSU and also to utilize the

Northwestern Medicine has enrolled its first participants in a new international clinical drug trial for COVID-19. The drug being tested is remdesivir, a novel anti-viral drug developed to treat Ebola and which has subsequently been found, in animal models, to have antiviral activity against coronaviruses including MERS and now SARS-Cov-2, the virus that causes COVID-19 disease. The randomized

A new study at Washington University School of Medicine in St. Louis will investigate whether two different antimalarial drugs, including hydroxychloroquine, alone or in combination with a common antibiotic, is effective in treating patients with COVID-19. The drugs to be used in the trial were donated by Cigna/Express Scripts, and the trial will include patients hospitalized with COVID-19 at

Expressive language sampling addresses urgent need in fragile X syndrome research and therapy A multi-university team of researchers found that expressive language sampling (ELS) can be useful in measuring outcomes in clinical trials targeting fragile X syndrome (FXS). According to their study, ELS, a set of procedures for collecting and analyzing spoken language in natural verbal interactions

UC Davis Health study a “big first step” in standardizing assessments Researchers at the UC Davis MIND Institute have updated and validated a series of tests delivered on an iPad to accurately assess cognitive processing in people with intellectual disability. The validation opens new opportunities for more rigorous and sensitive studies in this population, historically difficult to evaluate

Using the REDCap software platform, a team of researchers led from Vanderbilt University Medical Center have developed a new framework for electronic consent in clinical trials that’s designed to address both issues of transparency, efficiency and compliance while also improving participant recruitment and retention of under-represented minority groups. According to a preproof article for the

This week the academic health science libraries had the honor of doing a guest blog for Dr. Patti Brennan, Director of the National Library of Medicine. The post highlights the wide range of active COVID-19-related library partnerships across clinical care, education, research, resource access, and outreach. The hope is to spark new discussions and collaborations on campuses.

Press Release April 6, 2020 -- In response to the White House's call to action for the scientific community to help solve important COVID-19 questions, the Collaborative Archive & Data Research Environment (CADRE) project has created the Research Cohort for the Study of Coronaviruses (RCSC) fellowship program. The RCSC Program gives any researcher working on COVID-19 or coronavirus-related

NYU Investigators Seeking Eligible COVID-19 Positive Patients for Study

Christina Fournier, MD, Co-Director of the Emory Amyotrophic Lateral Sclerosis (ALS) Center and Georgia Clinical & Translational Science Alliance (Georgia CTSA) Master in Science in Clinical Research (MSCR) graduate, worked to create a highly innovative telemedicine system for Emory ALS Center patients in partnership with Dr. Jonathan Glass and the Emory ALS Center team. These patients can now

“When faced with a rising number of COVID-19 patients under investigation and that have the disease in the Grady Memorial Hospital ICU, we had to quickly mobilize and have discussions with all of our critical care colleagues to determine how to redeploy intensivists. A critical care task force was assigned to this COVID-19 pandemic to evaluate the current status and where we needed to be to handle

COLUMBUS, Ohio, (March 30, 2020)—Battelle and The Ohio State University Wexner Medical Center have jointly developed a new rapid, sensitive diagnostic test for COVID-19. The Ohio State Wexner Medical Center will administer the new test under its existing FDA certification permits. This will increase and improve test processing in Ohio according to existing state clinical guidelines. The new rapid

What innovations could help treat COVID-19 patients? How can we best approach po-tential pitfalls in hospital care during this pandemic? Can we retrofit hospital rooms so as to treat the large increase in patients during this crisis? How can health care profes-sionals most safely continue their work in this time? The GuideWire crew and a guest panel of health experts from UNC Health discuss how

The UC Davis CTSC Clinical Research Center is supporting two clinical trials underway for hospitalized patients with severe COVID-19, the disease caused by the novel coronavirus, SARS-CoV-2. The studies are evaluating the safety and effectiveness of two drugs — the investigational antiviral remdesivir, and sarilumab, a drug that blocks the body’s acute inflammatory response. “We have a critical

Nicholas Soulakis, PhD, assistant professor of Preventive Medicine in the Divisions of Health and Biomedical Informatics and Epidemiology, is taking a leave of absence from the medical school to work as an epidemiologist in the Illinois Department of Public Health’s (IDPH) Office of Policy, Planning and Statistics. Soulakis, who specializes in epidemiological surveillance, will help the IDPH

Not many executive bios begin with a crowning achievement in the eighth grade. “Graduating as class president from Horace Mann Elementary School was a big deal. My mom was a teacher there and it helped fulfil early dreams she had for me as I matriculated to St. Ignatius College Prep,” says Melvin Thompson, executive director of the Endeleo Institute, a nonprofit focused on creating a culture of

College classes. Dance parties. Happy hours. As social distancing sinks into daily life, people are discovering new and unique ways to do what they need to do remotely. And at Virginia Commonwealth University and VCU Health, some doctors are seeing a long-term project — to bring health care into our homes — gain some much-needed traction.

Help fight COVID-19 in 5 minutes a day! Mark Pletcher (UCSF CTSI Director of Informatics & Research Innovation), Gregory Marcus (Professor, Medicine) and Jeffrey Olgin (Chief, Division of Cardiology / Co-Director, Heart and Vascular Center)are using their Eureka Mobile Research Platform—an NIH funded digital research platform—to launch a world-wide study to track COVID-19 symptoms, infections

Georgia CTSA partners are working together in the fight against COVID-19. Yesterday, Georgia Tech delivered 5,000 face shields they designed and manufactured in-house to Emory Healthcare to protect our front line workers in the fight against COVID-19. The Georgia Tech team of professors and students are collaborating with Siemens to scale these creations to mass production. https://www.fox5atlanta

Rachel K. Scott, MD, MPH, FACOG, using data collected during her GHUCCTS clinical and translational science pilot award, was recently accepted for publication in AIDS Patient Care and STDs. Her manuscript, titled "Integrating HIV Pre-Exposure Prophylaxis into family planning care: a RE-AIM Framework evaluation", will appear in their next edition. Since her GHUCCTS pilot funding, Dr. Scott has been

Investigators with the Supporting Pediatric Research on Outcomes and Utilization of Telehealth (SPROUT) NCATS collaborative U01 hosted a nationwide call (March 12, 2020) in collaboration with the American Academy of Pediatrics Section on Telehealth to discuss how both adult and pediatric telehealth is being used in response to COVID-19 nationally. Nine leading healthcare institutions presented on

Dr. Thomas Mellman, GHUCCTS Co-PI and Professor of Psychiatry at Howard University, appeared on WHUR 96.3 to share advice on how we can deal with the stress, anxiety, and worry caused by the coronavirus crisis.

We're proud to announce that Wright Center Researcher Arun Sanyal, M.D., and a multi-disciplinary team have brought remdesivir coronavirus treatment trials to VCU. "We were able to get the trial off the ground, meeting all of the complex regulatory requirements along the way, within a 72-hour time frame, primarily because of the alignment of mission and vision and an extraordinary team effort from

REDCap, a software application created and developed at Vanderbilt University Medical Center, has found widespread use in the public health response to the COVID-19 pandemic. “We’re finding many instances — locally, regionally, nationally, and several international examples — where various groups are using REDCap to support COVID-19 surveillance,” said REDCap’s creator, Paul Harris, PhD, MS

With many of us either having newfound time at home or working in seemingly empty offices or labs, why not catch up with your newest favorite medical device innovation podcast? The North Carolina Translational and Clinical Sciences (NC TraCS) Institute, the integrated hub of the CTSA at the University of North Carolina at Chapel Hill (UNC-Chapel Hill) has launched the podcast GuideWire. On

Can a well-known spice help asthma patients breathe easier? That’s the question North Carolina Translational and Clinical Sciences (NC TraCS) Institute partner North Carolina Agricultural and Technical State University (N.C. A&T)'s Shengmin Sang and his colleagues at Columbia University are planning to study as the recipients of a four-year, $1.8 million R01 grant from the National Institutes of

“In a situation like this where everything is so new, scientific communication and the ability to interpret it becomes a critical issue. We’re talking about something that people, up until three months ago, have never dealt with,” says Dr. Jeffrey Collins. Jeffrey Collins, MD, MSc, Assistant Professor, and Russell Kempker, MD, MSc, Associate Professor, Emory University School of Medicine, Division

In light of current concerns regarding the COVID-19 (coronavirus), CD2H would like to communicate our efforts for increasing awareness with a community-developed website: www.flattenthecurve.com. Follow the links to volunteer to help spread the word.

Requested by The White House Office of Science and Technology Policy, the COVID-19 Open Research Dataset (CORD-19) represents the most extensive machine-readable coronavirus literature collection available for data and text mining to date, with over 29,000 articles, more than 13,000 of which have full text. Now, The White House joins these institutions in issuing a call to action to the Nation's

You are invited to contribute your best work for presentation at the AMIA 2020 Annual Symposium – the foremost symposium for the science and practice of biomedical informatics. AMIA 2020 Annual Symposium, held November 14-18 in Chicago, invites submissions from informatics researchers and practitioners around the world. Deadline for submissions is Wednesday March 18. Don't miss out!

After locking the spike protein in the shape it takes before fusing with a human cell to infect it, the researchers reconstructed its atomic-scale 3D structural map in just 12 days. Their results, published in Science, confirm that the spike protein on the virus that causes COVID-19 is quite similar to that of its close relative, the SARS virus. It also appears to bind human cells more tightly

Emory’s first coronavirus patient began receiving infusion therapy yesterday as a result of Georgia CTSA’s assistance in coordinating the approvals needed within 48 hours. Georgia CTSA’s Navigator Team utilized the new Standard Operating Procedure (SOP) for its Rapid Response Team service to obtain fast-track approvals across the Emory system. Sherry Coleman, DNP, RN, CHRC, Georgia CTSA Associate

Note: First author, Jennifer Graves, MD, PhD, received a 2015 UCSF CTSI Pilot Award in Digital Health, which supported this clinical trial work. A multi-sensor band worn on the arm or leg, called Myo, can capture and relay difficulties with limb movement due to multiple sclerosis (MS) with an accuracy that mirrors gold standard measures of disability, like the Expanded Disability Status Scale

Patients with inflammatory bowel disease (IBD) are frequently treated with immune suppression therapy. Do they face special risks associated with COVID-19? UNC Pediatric gastroenterologist Dr. Mike Kappelman, GI fellow Dr. Erica Brenner, and their collaborator Dr. Ryan Ungaro from the Icahn School of Medicine in New York want to find out. With help from the North Carolina Translational & Clinical

Pharmacy residents come to Mayo Clinic with varying levels of exposure to research. But all of them end their residency with equipped to interpret medical literature and to pursue research opportunities with confidence. A recent study found that pharmacy residents who take part in a research training program improve their knowledge scores. But the biggest changes are to their feelings of

The SC CTSI has joined forces with Hollywood, Health & Society, which is a health communications program based at the USC Annenberg Norman Lear Center, to consult with the writers and creators of popular television shows and movies about how to integrate content about health and clinical research into their storylines. After just three years, the initiative has paired USC scientists with producers

The DIAMOND project is interested in exploring collaborative opportunities between our respective CTSAs. DIAMOND is an NCATS-funded online learning community that showcases education and training resources for clinical and translational research professionals. The Diamond Portal is an online repository of competency-based education and training resources and assessment materials that have been

The Office of the National Coordinator (ONC) for Health Information Technology has published the final rule intended to move the health care ecosystem in the direction of interoperability to improve quality and accessibility of information. The rule implements the information blocking provisions of the 21st Century Cures Act in an effort to further support access and exchange of electronic health

Participant recruitment can be a tremendous challenge for clinical research, but a recent pilot program at the University of Rochester nearly tripled enrollment in a local clinical research registry - simply by engaging patients in person. Funded in part by the University of Rochester Clinical and Translational Science Institute (UR CTSI), the three-month pilot program aimed to improve enrollment

Dr. Alpha A. “Berry” Fowler III spoke about his sepsis research to the UK's Daily Mail in a story about Vitamin C inspired by the coronoavirus. Fowler is the associate director for Team Science at the Virginia Commonwealth Center C. Kenneth and Dianne Wright Center for Clinical and Translational Research. New research into the use of vitamin C therapy for sepsis — where the body’s immune system

The Washington University Institute of Clinical and Translational Sciences and Washington University’s Institute for Public Health announce six partnerships selected to receive funding through the new Partnership Development and Sustainability Support (PDSS) program. This funding program provides up to $10,000 to community-academic partnerships for a 12-month period. It enables partners to develop

The increased use of electronic cigarettes and vaping products has increased the need to better understand how and if addiction to these products is different than in traditional cigarettes. One way to objectively measure addictive potential is through changes in the brain, but researchers say a limited number of methods currently exist to deliver the vapor (called aerosol) during magnetic

For the ICTS, Valentine’s Day was all about the love of informatics. On February 14, the ICTS hosted their third annual Symposium and Poster Session held at the Eric P. Newman Education Center on the campus of Washington University School of Medicine in St. Louis. The day-long event featured presentations, breakout discussions, and a poster session focused on the application of informatics tools

Washington University Institute of Clinical and Translational Sciences (ICTS) awards 24 investigators with grants as part of the 13th annual Clinical and Translational Research Funding Program (CTRFP). The CTRFP is the largest internal grant funding program of the ICTS. Grant awardees are required to submit projects for funding that promote the translation of scientific discoveries into

CD2H is pleased to announce the projects for Phase III. Over 20 proposals, including ongoing infrastructure projects, were independently reviewed by a panel of community leaders, hub PIs, and the CD2H Steering Committee. Nine projects best fit the Phase III strategy, and will be facilitated within their respective CD2H cores under the direction of the core leaders, community co-chairs, and project

The University of Wisconsin Institute for Clinical and Translational Research (ICTR) is excited to share that our partners from the UW School of Veterinary Medicine (SVM) have recently announced the selection of the inaugural class of Translational Research Fellows for 2020. These fellows are part of a novel, multi-stage training program supported by a CTSA Innovation Award (U01TR002953)

Amy Olex, senior bioinformatics specialist at Virginia Commonwealth University's Wright Center, presented her research to top scientists and leadership of the National Institute of Health on Feb. 20 at the institute’s library in Bethesda.

Researchers and the participants who enroll in their clinical trials do not always speak the same language, making it difficult to share trial results with study participants. As a result, most clinical trial participants are not told the results of the study in which they were involved, though most would like to know, and most researchers would like to tell them, report National Institutes of

When you go to drink out of a water fountain, what you think may come out depends a lot on your background. For many people, especially in San Francisco, it is clean, pristine drinking water. Others, however, may be less trusting, and they imagine contaminated water or something that may make them or their children sick. Scientists and community advocates hope that it is something else entirely

When Dr. LaPrincess Brewer talks to African-American women about heart health risks, it helps that she looks like her target audience, she said. African-American women have the highest death rate from cardiovascular disease than any other ethnic group, Dr. Brewer, a Mayo Clinic cardiologist and health disparities researcher, said to a congregation of mostly African Americans at Christ's Church of

Research symposium at Johns Hopkins explores how clinicians can get the most out of advancements in digital health. Researchers with Johns Hopkins Medicine and computer scientists from Johns Hopkins University’s Whiting School of Engineering are analyzing thousands of abdominal scans in an effort to catch pancreatic tumors while they are still operable. Another computer scientist developed an

From Editor-In-Chief, Lars Berglund, MD, PhD (former UC Davis CTSA PI): There is a need for an expanded pool of well qualified reviewers to enhance the Editorial Board and ensure a timely handling of submissions. I would very much appreciate if you could nominate a candidate or two at your institution for Board membership, and encourage them to submit a notice of interest as well as their CV to

From Editor-In-Chief, Lars Berglund, MD, PhD (former UC Davis CTSA PI): There is a need for an expanded pool of well qualified reviewers to enhance the Editorial Board and ensure a timely handling of submissions. I would very much appreciate if you could nominate a candidate or two at your institution for Board membership, and encourage them to submit a notice of interest as well as their CV to

GHUCCTS recently hosted a free online webinar titled The Added Value of Partnerships in Research: Effectively Engaging Communities and Patients. This webinar is now available online. Engaging communities and patients throughout the study process can positively impact health research, particularly when addressing complex health problems. These partnerships can also increase competitiveness in

Penn State Clinical and Translational Science Institute's Community-Engaged Research Core awarded three planning grants to faculty and community-based organization teams. These planning grants are laying the foundation for projects that affect a variety of communities. “We are delighted to support these collaborative community-faculty partnerships in developing research programs to address

Photo: UAMS' Atul Kothari, M.D., meets with TRI Associate Director John Arthur, M.D., Ph.D., to vet his study for multisite collaboration in the Trial Innovation Network (TIN). At two seminars in December, clinical researchers at the University of Arkansas for Medical Sciences (UAMS) and Arkansas Children’s Research Institute (ACRI) learned about intriguing new possibilities for their research

Andrea Hobkirk, assistant professor of psychiatry and public health sciences, is studying the problem of relapse after addiction treatment. Recently a scholar in Penn State Clinical and Translational Science Institute's Early-Stage Investigator Program (KL2), Hobkirk left the program when she was successful in securing a career development award from the National Institute on Drug Abuse. Through

The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies (ACME POCT), based at the Emory University School of Medicine and the Institute for Electronics and Nanotechnology at Georgia Tech, is one of four NIH-funded Centers of the NIBIB Point-of-Care Technologies Research Network. Our Center’s mission is to assist and enable inventors and clinicians at a national level who have

What do you want to be when you grow up? For Adrian Vella, M.D., at age 10 it was a tough choice between “doctor” and “astronaut.” He chose “doctor.” After coming to Mayo Clinic, Dr. Vella changed that to “doctor and diabetes researcher.” Now, 25 years later, he has added one more job to the list: director of Mayo’s Clinical Research and Trials Unit. In his new role, he’s focused on giving other

Qualitative data—such as data from interview or focus group studies—has a unique value in understanding health behaviors and traits. It is often used to understand attitudes and preferences, as well as complex and hidden behaviors. Qualitative research has led to deeper understandings of risk factors for HIV, teen pregnancy, and illegal drug use. When participants are asked to share information

Breakthrough research is rarely accomplished in a vacuum. Years of training, time spent writing and countless hours coordinating resources is an inherent part of any researcher’s work on the path to a successful study. Such is the case for Stephanie Fritz, MD, MSCI, ICTS member and senior author of a new study on how the superbug methicillin-resistant Staphylococcus aureus (MRSA) is introduced

Celebrating ten years of shared infrastructure and programs that accelerate research and improve health, UC BRAID convened its annual meeting on October 14-15, 2019 at the UCLA Luskin Conference Center. UC BRAID, the University of California Biomedical Research Acceleration, Integration, & Development, is a consortium of the five UC academic medical centers—Davis, Irvine, Los Angeles, San Diego

The Center for Evidence-based Policy at Oregon Health & Science University (OHSU) recently launched CLOUD: Curated Library about Opioid Use for Decision-makers. CLOUD is a user-friendly, online repository of evidence-based, actionable materials on opioids and the opioid crisis. The opioid library has three specific audiences in mind: payers & providers, policymakers & community leaders, and

Dr. Amanda Bruegl, OHSU oncologist and OCTRI KL2 awardee, has been named a scholar of the Harold Amos Medical Faculty Development Program, which is part of The Robert Wood Johnson Foundation. Dr. Bruegl will leverage this prestigious award to expand her research on HPV and cervical cancer in Native American women.

Mayo Clinic Proceedings recently added a new section, The Compass, which aims to promote discussion and analysis of bioethics issues, "questions of moral and clinical decision-making.” Some hot topics include artificial intelligence, burnout, financial conflicts and other emerging and under-examined issues. "We're attempting to fill an unmet need within the medical literature, where these ethical

Dr. Shaikh is Professor of Pediatrics at the University of California Davis School of Medicine and Clinical Quality Officer at the UC Davis Health Practice Management Group. She has authored more than 70 peer-reviewed and invited publications, largely focused on improving health care delivery. “Dr. Shaikh has led efforts to improve the quality of care for children through local, state, national

Denisse Vega-Ocasio, a student in the Translational Biomedical Sciences PhD Program at the University of Rochester Clinical & Translational Science Institute, is among 40 young science leaders who have been selected for a year-long fellowship at the Yale Ciencia Academy for Career Development. This highly-competitive program provides doctoral students from underrepresented backgrounds in the life

Michael Samaan, PhD, who is trained as a mechanical and biomedical engineer, specializes in biomechanics. His research received a boost when he received a career-development award in early 2019 from the UK Center for Clinical and Translational Science’s KL2 program. His study published in the January issue of Clinical Biomechanics helps shed light on the short-term outcome of arthroscopic surgery

UC Davis CTSC KL2 Scholar Ian Koebner, MD initiated a novel study to manage chronic pain. Over 100 million American adults suffer from chronic pain. This is more than those with heart disease, cancer, and diabetes combined. Chronic pain is complex. It affects the body, the mind, and social interactions. Previous studies show that social disconnection can cause pain to feel more intense. Studies

Losing more than a dozen family members to chronic hepatitis infection, liver cancer and other liver disease motivated Essa Mohamed to get a Ph.D. in clinical and translational science from Mayo Clinic Graduate School of Biomedical Sciences and make it a daily goal to improve the lives of others. Learning that liver disease is more prevalent among Africans and Asians launched him on a mission to

University of North Carolina at Chapel Hill (UNC-Chapel Hill) Department of Family Medicine professor and vice chair of research, Katrina Donahue MD, MPH, has been appointed to the U.S. Preventive Services Task Force (USPSTF). The Task Force is an independent, volunteer panel of national experts in prevention and evidence-based medicine. Members come from primary care and prevention-related fields

See the outstanding commentary by Ken Mandl and Isaac Kohane. It's time to make healthcare a truly data- and knowledge-driven enterprise. That begins by making sure responsible, scalable, and technology-agnostic data sharing is the norm and not an exception!

Dr. David Sheridan, Assistant Professor of Emergency Medicine, and his team at Oregon Health & Science University are developing a wearable device that assesses and reports the physiological measures associated with stress dysregulation and worsening suicidality. The goal is to help adolescents identify these symptoms and therefore allow time for interventions that can help prevent emergency

The success of antiretroviral therapies has extended the lives of people living with HIV, long enough for other chronic health conditions to emerge, including a recently documented uptick in sudden death. Now, in a study comparing medical information and portable EKG patch data from men living with HIV to men without it, Johns Hopkins Medicine researchers and collaborators report they have found

The last days and hours of 2019 marked not only the end of a decade, but also the completion of patient enrollment in a landmark randomized clinical trial on the duration of anti-clotting medication (anticoagulant) therapy for venous thromboembolism (VTE) in patients under 21 years old — the Kids-DOTT trial. VTE, which includes blood clots in the deep veins of the legs, arms, other areas of the

Jennifer Ronnenberg has lived with cystic fibrosis for years. But last year, thanks to a double lung transplant, she was able to start breathing on her own. Jennifer is the guest of honor at a screening of "Five Feet Apart" hosted by the Mayo Clinic Bioethics Research Program. During the discussion panel that follows, community members will have the opportunity to ask her about her experience as a

The UNC School of Medicine, UNC Lineberger Comprehensive Cancer Center, and UNC Center for Health Equity Research are hosting the Inaugural Paul A. Godley Health Equity Symposium on March 5, 2020 to bring together faculty, staff, students, and the community to highlight and encourage health equity research, promote collaboration and networking, and encourage strategic planning and partnerships at

Lincoln eighth-grader Sydney Schulz says she hears older students say vaping oils are harmless. Lab research she conducted herself says otherwise. She and her peers have been observing the effects of those oils on developing zebrafish. The students are taking part in Mayo Clinic's Integrated Science Education Outreach — InSciEd Out — program that works with K-12 students. InSciEd Out was initiated

A team of addiction researchers at the Medical University of South Carolina (MUSC) report in Psychopharmacology that oxytocin, a hormone produced naturally in the hypothalamus, has significant gender differences when used as a treatment for cocaine-addicted individuals with a history of childhood trauma. The MUSC team was led by Jane E. Joseph, Ph.D. (pictured here), a professor in the Department

Meet Dr. Rebecca Spain, a neurologist at OHSU.

A new research unit that will greatly expand the capacity for scientists to conduct clinical trials is set to open at the University of Kansas Medical Center on Jan. 13. It will be the first clinical and translational science unit (CTSU) on the main KU Medical Center campus in Kansas City, Kansas. The new CTSU Rainbow builds on the success of the CTSUs in Fairway, Kansas, the KU School of Medicine

As a result of clinical trials conducted in the CCTSI’s pediatric Clinical and Translational Research Center (CTRC) at Children’s Colorado, ther US FDA has approved new breakthrough therapy for cystic fibrosis (CF), a genetic disease that leads to lung, digestive, endocrine and nutritional problems. Researchers from Children’s Hospital Colorado were part of a national network that oversaw clinical

The Robert Wood Johnson Foundation (RWJF) is working alongside others to build a national Culture of Health that provides everyone in America a fair and just opportunity for health and well-being. The foundation is facing many obstacles that pose challenges to this audacious vision—inequities in life expectancy across communities; high-cost health care but poorer quality of care and health; and

Penn State Clinical and Translational Science Institute announces its Biostatistics, Epidemiology and Research Design (BERD) Research Methods Seminar Series schedule for the spring 2020 semester. The Research Methods Seminar Series features lectures on advanced topics in the spring semester and fundamental research methods in the fall semester. Statisticians and methodologists from multiple Penn

A study led by Mayo Clinic KL2 Mentored Career Development scholar, Marina Walther-Antonio, Ph.D., recently examined the role of post menopause in the composition of endometrial cancer microbiome. “If the microbiome does play a role in endometrial cancer, beyond being a marker for it, this could have important implications for endometrial cancer prevention,” says Dr. Walther-Antonio. Overall, the

The North Carolina Translational and Clinical Sciences (NC TraCS) Institute posts a bit of helpful advice concerning applying to grants to readers of our weekly publication. This month's grant tip concerned grammar in grant writing: When writing a grant application with the goal of getting your message across to the reader, you can communicate not just through the facts you present, but also how

F. Gerard Moeller, M.D., director of Virginia Commonwealth University’s Wright Center for Clinical and Translational Research, a CTSA-funded institution, participated in a panel discussion hosted by the Duke Margolis Center for Health Policy, on Dec 17. The panel explored the history of developing drug therapies for stimulant use disorder and the barriers researchers have faced when evaluating the

Tippi MacKenzie, MD, UCSF-CTSI Catalyst Program Awardee, was recently featured in an in-depth news story about her team's pioneering approaches in fetal gene therapy. By the time a baby is born with a catastrophic genetic disease, medical help is too little, too late. UC San Francisco doctors are studying a bolder and better remedy, far earlier: repairing genes before birth, stopping disease

Entrepreneurs chomped at the chance to present exciting new health care projects at the Alligator Tank competition, held Nov. 19 at Mayo Clinic in Florida. About 100 people showed up in Kinne Auditorium—at times standing room only—to watch eager contestants put everything on the line and give their best performance. Like the "Shark Tank" television concept, presenters or teams had two minutes to

Arun Sanyal, a professor of Medicine and co-director of the Wright Center for Clinical & Translational Research's education core, has helped establish the scientific foundation for what may soon become the first approved drug therapy for NASH, a severe form of fatty liver disease closely related to obesity and Type 2 diabetes. Patients with nonalcoholic steatohepatitis (NASH), a chronic liver

AnelleO, a UNC spinoff company, is working to make a customizable drug-delivery platform for women a reality with their first product – AnelleO PRO, a progesterone-releasing intravaginal ring for treatment of infertility. AnelleO was founded by Rahima Benhabbour, PhD. Benhabbour, an Assistant Professor in the UNC/NC State Joint Department of Biomedical Engineering and an NC TraCS KL2 Scholar (2015

Natural language processing, the technology that lets computers read, decipher, understand and make sense of human language, is the driving force behind internet search engines, email filters, digital assistants such as Amazon’s Alexa and Apple’s Siri, and language-to-language translation apps. Now, Johns Hopkins Medicine researchers say they have given this technology a new job as a clinical

Face-jaw-teeth transplants are one of the most complicated surgeries due to differences between the donor and recipient. This month, the United States approved a patent submitted by a Johns Hopkins research team for a new way to perform facial transplants. The Computer Assisted Planning and Execution System (CAPE) method aids surgeons in planning and performing craniomaxillofacial surgery—a

Megan Allyse, Ph.D., is no stranger to speaking to a crowd. Dr. Allyse, a biomedical ethics researcher at Mayo Clinic, teaches medical students and makes frequent presentations to community groups. But recently she spoke to an audience she rarely encounters: a group made up entirely of people under 18. "The youngest was 11," Dr. Allyse says. "He had so much to say." Dr. Allyse was presenting to

When it comes to cholesterol, we’ve come to accept a simple narrative. Our risk of heart disease is lower when we have more “good cholesterol,” or high-density lipoproteins (HDL), and less “bad cholesterol,” or low-density lipoproteins (LDL) and triglycerides. Complicating this narrative, however, is the higher risk of severe heart disease in African Americans, despite the fact that they tend to

Research on the Ehlers-Danlos Syndromes, a group of rare heritable disorders of connective tissue, is supported through Penn State Clinical and Translational Science Institute. The institute funded two pilot projects through its Bridges to Translation Pilot Grant Program. The first pilot grant led to the acquisition of a dataset for analysis and Penn State’s involvement with the Ehlers-Danlos

Twice a week, veterans and active-duty service members and their families gather at Folly Beach in Charleston, South Carolina. There, they learn the art of surfing with help from instructors and wellness coaches from the Warrior Surf Foundation. But this surf instruction has a therapeutic twist. It not only enables veterans to gain surf skills but also uses surfing as a vehicle to teach techniques

Shuvo Roy, PhD, is a four-time UCSF CTSI Catalyst Program Awardee, for different applications of his silicon membrane technology including for the kidney, artificial pancreas and high efficiency external ambulatory lung. The project team received a Fall 2017 Catalyst Award to collect data on their artificial kidney membrane prototypes and provide sterilization procedures information to the FDA as

Precision medicine has arrived, but many physicians do not have the training or time to incorporate genetic sequencing technologies into everyday practice. In two new articles published online in the Annals of Internal Medicine, precision medicine experts at Columbia University Vagelos College of Physicians and Surgeons and Co-Directors of the Irving Institute’s Precision Medicine Resource, Drs

A genomic incompatibility could explain why many kidney transplants fail, even when donors and recipients are thought to be well-matched, a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons suggests. The co-senior author is Dr. Krzysztof Kiryluk, Herbert Irving Assistant Professor of Medicine and Co-Director of the Irving Institute’s Precision Medicine

When it comes to nicotine delivery, not all electronic cigarettes are created equally, according to Penn State researchers. New research from Penn State College of Medicine shows that JUUL, a popular pod-based electronic cigarette, can deliver more nicotine at a faster rate than most other types of electronic cigarettes that have been studied. Jessica Yingst, first author and researcher at the

A USC pilot study has indicated that an occupational therapy intervention can help diabetes patients make the kind of important and long-lasting lifestyle changes that have the potential to substantially improve their health and prevent serious health complications. The study by KL2 alumna Beth Pyatak, PhD, OTR/L, CDE, is part of a novel academic-government collaboration between the SC CTSI, the

Martin County has been experiencing a water crisis for decades, with the 8th highest cost of water in the state. A participant of the CCTS Community Leadership Institute of Kentucky co-authored a report how residents, many of whom can’t afford their water bills, are impacted.

LEXINGTON, Ky. (Oct. 22, 2019) – A new clinical trial initiated by University of Kentucky researchers argues against the hypothesis that the diabetes drug metformin could help exercising seniors gain more muscle mass. The double-blind trial, conducted at the University of Kentucky and University of Alabama at Birmingham, found that older adults who took metformin while performing rigorous

The North Carolina Translational and Clinical Sciences (NC TraCS) Institute is excited to announce Research for Me @UNC, a public-facing website that will encourage knowledge of and participation in research across the University of North Carolina at Chapel Hill (UNC-Chapel Hill). This site is a comprehensive response to the challenges of research engagement that arise for both the public and

Penn State Clinical and Translational Science Institute generates innovative health research ideas and promotes collaboration through its Bridges to Translation pilot grant program. This program seeks to link researchers not traditionally in health research with those who can help mold a new idea. These grants allow researchers to explore new ideas and gather information in preparation for more

Dermatologist Iris Z. Ahronowitz, MD, and her team used a wealth of data at USC for a first-ever retrospective study involving a majority Hispanic population of solid organ transplant recipients. The research team, which was supported by a Team Building Grant from the Southern California Clinical and Translational Science Institute (SC CTSI), included dermatologists, oncologists, and transplant

For some researchers who spend their days tucked away in a lab, the impact of their work may at times seem removed from the lives of real people. Not so for Dr. Kevin Messacar, pediatric infectious disease specialist. In his mind, he has considered himself a physician first, researcher second since he came to Children’s Hospital Colorado in 2009. Yet over the past several years, Messacar’s

UCLA's David Shackelford and colleagues have identified a new biomarker that could indicate how likely someone is to respond to treatment for lung cancer. In a test using mice, the scientists found that the level of activity of the mitochondria in lung tumor cells could potentially predict who would respond favorably to a type of drug called a complex I inhibitor, which targets mitochondrial

Sent on behalf of Drs. David McManus and Bryan Buchholz, PIs of the Center for Advancing Point of Care Technologies Dear Colleague, We want your expert opinion about what qualities of point of care technologies (POCTs) are most important to clinicians. Moreover, we would like to better understand the decision-making process of implementing these newer technologies into everyday practice. Our hope

Speeding the translation of discovery in the laboratory to the clinic and the community is the goal of the more than 60 Clinical & Translational Science Awards Program (CTSA) hubs funded by the National Center for Advancing Translational Sciences (NCATS). But how does each hub know its efforts are working and measure the overall impact of its program? How does it compare its efforts to those of

Meet Allisa Song: Medical Student, Inventor, and Startup Company Co-founder. "Our main goal has always been to help empower patients to take back control of their eye health in our complicated health care system.” Allisa Song is a second-year medical student at Mayo Clinic Alix School of Medicine in Rochester, Minnesota. In 2017 she brought together the team that developed the Nanodropper, a

Move over, apples — new research from Penn State suggests that eating one avocado a day may help keep “bad cholesterol” at bay. According to the researchers, bad cholesterol can refer to both oxidized low-density lipoprotein (LDL) and small, dense LDL particles. In a randomized, controlled feeding study, the researchers found that eating one avocado a day was associated with lower levels of LDL

On September 27- 29, 2019, staff from the North Carolina Translational and Clinical Sciences (NC TraCS) Institute Research Coordination & Management Unit (RCMU) including Caroline Buse, Catherine Barnes and Laura Viera attended The Society of Clinical Research Associates (SoCRA) 28th annual conference. The conference brought in over 1,000 research professionals from across the world, featured over

A team of researchers at the Medical University of South Carolina (MUSC) has been awarded $3.75 million by the National Center for Advancing Translational Sciences to enhance an existing informatics tool known as “informatics for integrating biology and the bedside” or I2B2. The MUSC team will enhance I2B2 so that it can better identify Emergency Department cases of nonfatal opioid overdose. The

Driven to solve an everyday problem and help patients, Drs. Christine Mehner and Toni Turnbull designed a new adjustable nail to set long bone fractures in orthopedic surgery. Their idea could simplify surgery for physicians and reduce side effects for patients. These innovators developed their idea with valuable feedback from a Mayo Clinic life sciences pitching competition.

The American Journal of Geriatrics published a letter to the editor by Meredith Zauflik, MPA, Recruitment Specialist at OCTRI (Portland's CTSA hub) and Elizabeth Eckstrom, MD, MPH, Director of Integrating Special Populations at OCTRI and Chief of Geriatrics at Oregon Health & Science University. In “Matching Older Research Subjects to Disease Demographics: First You Need to Know the Demographics,”

Advancing understanding of human health promotion and disease prevention and treatment often requires teamwork. To evaluate academic medical institutions’ support for team science in the context of researchers’ career development, a team led by Penn State Clinical and Translational Science Institute's Susan McHale, Ph.D., measured the value placed on team science and specificity of guidance

What is CEREC? CEREC was established in 2016 to provide an outlet for obtaining external reviews for CTSA-funded pilot research and to minimize the likelihood of bias and conflicts of interest. CEREC also offers a larger pool of expertise from which to draw precisely matched reviews for scientific lines of inquiry that may not be well represented within the institution receiving the proposal. This

Almost 700,000 U.S. children are abused each year. Many more children are traumatized by bullying, crime, domestic violence, food insecurity or a family member with untreated mental health or substance use issues. Traumatic experiences in childhood can have long-term consequences for mental and physical health. Good evidence-based treatment is available for trauma. However, only about a third of

The National Institutes of Health (NIH) awarded a research team from George Washington (GW), Yale, and Duke Universities $7.8 million to establish a rare disease network for Myasthenia Gravis. The team is led by Henry Kaminiski, MD (GW) and includes Linda Kusner, PhD (GW), Alison Hall, PhD (GW), Jeffrey Guptill, MD (Duke), Richard Nowak, MD (Yale), and Kevin O'Connor, PhD (Yale) as project leaders

AnelleO, a UNC spinoff company, is working to make a customizable drug-delivery platform for women a reality with their first product – AnelleO PRO, a progesterone-releasing intravaginal ring for treatment of infertility. AnelleO was co-founded by Rahima Benhabbour, PhD and Rima Janusziewicz, PhD. Benhabbour, an Assistant Professor in the UNC/NC State Joint Department of Biomedical Engineering and

Researchers at Virginia Commonwealth University this week were awarded two grants totaling more than $2.6 million through the National Institutes of Health Helping to End Addiction Long-term Initiative, or NIH HEAL Initiative, to improve treatment for opioid addiction. VCU’s School of Pharmacy, School of Medicine and C. Kenneth and Dianne Wright Center for Clinical and Translational Research will

Earlier this year, Erik Burlingame and Geoff Schau of the Biomedical Engineering Graduate Program and Computational Biology Program at Oregon Health and Science University pitched their proof-of-concept to judges at the InventOR Collegiate Challenge. They won the competition’s Impact Award, taking home a $5,000 prize and validation that their idea had business potential. Early funding for their

A SC CTSI-supported study by Lorraine Kelley-Quon, MD, a pediatric surgeon at Children’s Hospital Los Angeles and assistant professor at the Keck School of Medicine of USC, found that teens who used opioid pills were more likely to try heroin.

Mark Toles, PhD, RN, Assistant Professor in the University of North Carolina at Chapel Hill School of Nursing and a NC TraCS KL2 Scholar (2014-2017), has continued his work with the Connect-Home transitional care process that he developed during his time as a TraCS KL2 Scholar. Connect-Home is an evidence-based process that helps patients and their caregivers manage serious illnesses at home

Trainees, scholars, students, and pilot award recipients who recently presented their work at the University of Florida Clinical and Translational Science Institute, or CTSI, and M.D.-Ph.D. Training Program’s Research Day heard a unique perspective from a keynote speaker who’s been featured in the New York Times and the New England Journal of Medicine — and who owes her life to research. The

Graduate students with varied research interests including placental disease, movement and the brain, immune response to a bacterial pathogen, protein structure in neurons, DNA mutations in breast cancer, parent feeding practices, and behavioral inhibition have started a year of training in clinical and translational sciences. The TL1 Translational Research Training Program is a yearlong

The Oregon Clinical and Translational Research Institute (OCTRI) Community Research Hub is working to improve the health and wellness of all Oregonians. They engage researchers, community members and local organizations to include a community voice in research. The OCTRI Community Research Hub partnered with Tillamook County to evaluate and develop next steps for the Tillamook Year of Wellness

Restricting sleep for just several days alters how we metabolize fats and changes how satisfied we are by a meal, according to new research conducted at Penn State and published in the Journal of Lipid Research. According to Orfeu Buxton, researcher on the project and professor of biobehavioral health at Penn State, when we don’t get enough sleep, we want to eat more than we need, and store it as

Dr. Carter is like a ship’s navigator, but for research. He and his team in the Biostatistics, Epidemiology and Research Design program help investigators plot promising courses through uncharted waters. On occasion, the team helps rescue researchers trapped in data analysis doldrums. “It’s all about growing Mayo research and keeping it moving forward,” says Dr. Carter.

Katie Amaral researches forensics; Dr. Nazia Raja-Khan studies the use of mindfulness for diabetes. While these are very different research topics, Amaral and Raja-Khan’s desire to help communities is a commonality that attracted both to Penn State Clinical and Translational Science Institute's Community-Engaged Research Core Faculty Fellowship. The program expanded this year to include two Penn

In a new study of seven people with Parkinson’s disease, Johns Hopkins Medicine researchers report evidence that deep brain stimulation using electrical impulses jumpstarts the nerve cells that produce the chemical messenger dopamine to reduce tremors and muscle rigidity that are the hallmark of Parkinson’s disease, and increases feelings of well-being. “While deep brain stimulation has been used

Wentao Li, PhD, postdoctoral research associate in the Sancar lab at the University of North Carolina at Chapel Hill, received a K99/R00 Pathway to Independence Award from the NIH to further his studies on the role of aflatoxin-induced DNA damage and its repair in hepatocellular carcinoma, a type of liver cancer. Underpinning Li’s Pathway to Independence Award is a TraCS $2K pilot award,

Rare diseases by definition afflict a limited amount of people. However, according to the National Center for Advancing Translational Sciences (NCATS), the collective impact of rare diseases affect an estimated 30 million people in the United States. As part of the CTSA program, the ICTS is working to engage patients and communities around rare disease. One way the ICTS aids rare disease research

The ICTS Precision Medicine function recently co- sponsored a community presentation and discussion under the context of the New York Times Bestseller, The Immortal Life of Henrietta Lacks, to facilitate conversation around key ethical considerations of precision medicine. The event, hosted by the Academy of Science of St. Louis, included a presentation about the Henrietta Lacks story and how her

Oregon Clinical and Translational Research Institute, the CTSA hub at Oregon Health & Science University in Portland, OR, is the primary research and evaluation partner for the PSU BUILD-EXITO program, which is designed to increase diversity in science starting with undergraduate students. EXITO students receive intensive mentoring and instruction on how scientific research is performed, then

The OHSU Week podcast series features news and information for the OHSU community. This episode focuses on the investigation and discovery that drive OHSU’s research environment. Guests include team members from the Portland CTSA hub, Oregon Clinical & Translational Research Institute (OCTRI). Jonathan Jubera, MBA, Project Manager, and Melissa Mudd, MPH, Research Associate, discuss the innovation

Translating research into tangible results - medications, devices, software, and more. Oregon Clinical & Translational Research Institute's (OCTRI) inaugural podcast introduces how we support clinical investigators who are creating new solutions in health care. This podcast was created to share stories that illustrate our mission: Supporting the translation of research ideas into tangible results

The Fast Healthcare Interoperability Resources (FHIR® fhir.hl7.org ) specification is becoming to clinical data what HTML is to the web — a scalable mechanism to render clinical data in a way than people and machines alike can understand. The now well-understood advantages of leveraging FHIR for clinical research were ratified by the unprecedented recent notice from the Office of the Director at

For Cynthia Lacey, the time, money and sheer energy it took to get to appointments in Hershey were an increasing challenge as her symptoms of ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease, progressed. The resident of Tobyhanna, Pennsylvania, located two hours northwest of Hershey, considers herself fortunate to be a patient at the Penn State Health Milton S

Sage Bionetworks has partnered with NCATS, the CTSA Program Center for Data To Health (CD2H), and the University of Washington to launch the Electronic Healthcare Record (EHR) DREAM Challenge .

Evidence-based profiles of roles across the translational workforce are now available through CTS-Personas, a project of the CTSA Program National Center for Data to Health (CD2H), led by Sara Gonzales at Northwestern University.

On a recent summer day in Sharon, Pennsylvania, Dr. George Garrow ate lunch at café, a product of the former steel town’s revitalization efforts. A woman approached him as he sat eating. “You probably don’t remember me,” she said, sheepishly, as she mentioned a medical issue he helped her with, and about dogs that she had talked in length about in the past. “Of course!” Garrow said with a smile.

Alberto Rubio Tapia, M.D., came to Mayo to start his career in academic medicine. Even before finishing his fellowship, he has already become an internationally recognized expert on celiac disease. He recently served as first author on the American College of Gastroenterology celiac disease guidelines. He also recently received the Mayo Clinic Alumni Association Donald C. Balfour Award for

The conference aims to identify the promise of ultra-high field MRI at addressing unmet clinical needs, highlight the current and future technologies required to fully exploit 7T in addressing these applications, and discuss the cost-benefit question, “Does the availability of 7T improve clinical outcomes?”.

The Innovation Center for Biomedical Informatics (ICBI) at Georgetown University is excited to announce their 8th Annual Health Informatic and Data Science Symposium. The symposium will be held on Friday, October 18, 2019 at the Georgetown University Conference Center. Dr. Laura Esserman, Director of the Carol Franc Buck Breast Care Center and Dr. Eric Perakslis, Rubenstein Fellow at Duke

Researchers at the University of North Carolina at Chapel Hill have developed a method to identify patients with aggressive breast cancer that goes beyond the more familiar method of classifying a cancer based on tumor size, spread, tumor subtype, or molecular subtype. The ultimate goal of this work is to provide clinicians with critical information regarding patient response to treatment. This

Virginia Commonwealth University assistant professor Salvatore Carbone, Ph.D., smiles as he fondly recalls dinners with his family during summers spent in Sperlonga, Italy, a coastal town overlooking the Mediterranean Sea. “Extra-virgin olive oil was on everything, from pasta to fish and vegetables,” he said. The Italy native joined VCU to study under Antonio Abbate, M.D., Ph.D., soon after

As a nurse at Virginia Commonwealth University Medical Center’s Medical Respiratory Intensive Care Unit, VCU School of Nursing clinical assistant professor Tracye Proffitt met with a former ICU patient when he returned to the hospital a year after leaving to present to the nursing staff. “He talked about his memories of experiencing delirium in the ICU,” she said of the former patient who spent

Imagine this: You’re walking down the street in the middle of the day when you encounter a stranger crouched and crying on the sidewalk. Is your instinct to comfort the person or to use their emotional vulnerability to hurt them? “Most people can sense when others are in pain,” said David Chester, Ph.D., an assistant professor of psychology at Virginia Commonwealth University. “Whereas non

Researchers from RTI International and the University of North Carolina at Chapel Hill analyzed results from 22 studies in a systematic review. Based on this data, the researchers concluded that combination therapy can improve outcomes for some rheumatoid arthritis patients. Katrina Donahue, MD, MPH, lead author on the systematic review, is Co-Director of the North Carolina Network Consortium

Please join us at the 2019 Telehealth Research Symposium, September 11-13, 2019 in Chicago, IL. Join other connected health researchers, academicians, and telehealth visionaries for this three-day event to share findings and foster research partnerships. The event will include topics relevant in both adult and pediatric telehealth, as well as opportunities for more targeted learning. REGISTRATION

As a Wright Center KL2 Mentored Career Development Scholar, Virginia Commonwealth University School of Medicine associate professor April Kimmel, Ph.D., researched HIV care delivery models and access to care in the South. Among her findings was the discovery that a third of the population she studied had to travel more than an hour to receive comprehensive HIV treatment “My research is focused on

Marina Walther-Antonio, Ph.D., is heading the development of a home-based test for human papillomavirus to address high cervical cancer rates linked to widespread sexual violence in the Democratic Republic of Congo. The team has been at it for three years and they’re getting ready to start phase 1 clinical trials. Realistically, within a few years, a woman in the DRC could be handed a test kit

The SMART IRB team has published a new paper that provides background and updates on the platform and Agreement. Excerpt from abstract: Single institutional review board (IRB) review of multisite research increased in frequency over a decade ago with a proliferation of master IRB reliance agreements supporting statewide and regional consortia and disease- and population-specific networks. Although

A study funded through the Virginia Commonwealth University C. Kenneth and Dianne Wright Center for Clinical and Translational Research found that family medicine physicians often overestimate the geographic footprint of their practice. “It is important for a doctor to know where their patient comes from,” said study co-investigator Alex Krist, M.D. Krist serves as the co-director of community

Supporting cross-disciplinary research is one of the primary goals of Virginia Commonwealth University’s C. Kenneth and Dianne Wright Center for Clinical and Translational Research. Established in 2007, the center provides resources to encourage collaboration among VCU investigators and students, community partners and government organizations to advance the scientific study of human health. Last

Researchers from the University of North Carolina at Chapel Hill School of Medicine, the home of the North Carolina Translational and Clinical Sciences (NC TraCS) Institute, will collaborate with the North Carolina Department of Public Safety and the Durham County Sheriff’s Office to implement and evaluate two new opioid addiction treatment programs for people in the criminal justice system. Both

There are upwards of 7,000 geriatricians in the United States, only a handful are prepared to do geroscience. “Trained geroscientists are urgently needed to facilitate clinical trials that target fundamental aging mechanisms,” says Robert Pignolo, M.D., Ph.D., chair of the division of Geriatric Medicine and Gerontology and director of the Translation and Pharmacology Program at Mayo’s Robert and

The space and staff of any clinical research study can have an impact on the retention of participants and success of the trial. For pediatric clinical research, which includes infants to adolescents, these factors may weigh even more. Parents go out of their way to have their children participate in research, so a welcoming, professional environment makes all the difference. Michael D. Cabana, MD

Evaluators have strongly felt that more strategic approach to CTSA Evaluation is needed. The authors recognize the need to have a guiding document that can be used for the entire consortium. In late 2017 a group of evaluators formed the Clinical and Translational Sciences Awards (CTSA) Evaluation Guidelines Workgroup, co-chaired by Tanha Patel (Wake Forest) and Julie Rainwater, PhD (University of

Howard University, one of the five member institutions that comprise the Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS), has recently launched the NIH-Howard University Intramural Research Collaboration (NIH-HUIRC). This partnership with the National Institute of Health (NIH) Intramural Research Program will provide Howard students and junior faculty with

Research from Penn State Clinical and Translational Science Institute on the societal costs of the opiod epidemic is featured in a supplement from the The American Journal of Managed Care.The supplement will inform a variety of community audiences including policymakers. The supplement also explores the effect of the crisis on state governments, including the costs to employment and labor market

When scientists from different disciplines collaborate – as is increasingly necessary to confront the complexity of challenging research problems – interpersonal tussles often arise. One scientist may accuse another of stealing his or her ideas. Or, a researcher may feel he or she is not getting credit for their work or doesn’t have access to important data from the study. However, with the

Most people feel they have a general idea of how healthy they are based on their diet and exercise regimen and how often they get sick. However, a new study being conducted by researchers at Johns Hopkins Medicine is contributing to evidence that a person's perception of how healthy they are isn’t always an accurate indicator of their risk for cardiovascular disease. In a study of medical

In a pilot study of 14 older adults with mild cognitive problems suggestive of early Alzheimer’s disease, Johns Hopkins Medicine researchers report that a high-fat, low-carbohydrate diet may improve brain function and memory. Researchers say that finding participants willing to undertake restrictive diets for the three-month study — or partners willing to help them stick to those diets — was

While working with HIV-positive patients at an infectious diseases clinic in Jacksonville, Florida, Larry Keen, Ph.D., met many people who used marijuana to treat pain. “They would roll a joint while on pain medication,” Keen said. “I was like, ‘You never worry about how the marijuana and pain meds are interacting?’ And they looked at me and were like, ‘Why?’” The question seemed obvious to Keen

Starting grass roots efforts to improve support and advance the treatment for patients with a rare disease can be extremely challenging. It requires passionate patient advocates with persistent determination. It is also critical to have the support of medical institutions and other advocacy organizations. One patient advocate in Kansas City is pulling together all the pieces to make specialized

Frontiers awarded a total of $20,000 to 10 medical students to support summer research projects. These stipends allow Frontiers to contribute to the pipeline of professional development for students interested in clinical and translational research. "Frontiers is committed to offering medical students the opportunity to learn how interesting and rewarding research is early in their professional

When scientists from different disciplines collaborate – as is increasingly necessary to confront the complexity of challenging research problems – interpersonal tussles often arise. One scientist may accuse another of stealing her ideas. Or, a researcher may feel he is not getting credit for his work or doesn’t have access to important data. Northwestern University Clinical and Translational