Developing new therapies and getting them to patients is long and difficult. During public health emergencies, such as the Covid-19 Pandemic, science must move faster than ever. That is where translational science comes in. Translational science is focused on streamlining the process of moving (“translating”) lab findings into medical practice and treatments to improve health and well-being.
NCATS is supporting research activities spanning the translational science spectrum to address the novel coronavirus 2019 (SARS-CoV-2) and the disease it causes (COVID-19). To accelerate translational research, NCATS has developed research tools, technologies, expertise and collaborative networks that can quickly pivot to address urgent public health issues.
- The mission of the Irving Institute for Clinical and Translational Research is to advance discoveries, knowledge, and innovation to improve human health across the lifespan for diverse populations in upper Manhattan and around the world. By mobilizing and connecting Columbia University’s researchers, we aim to create a seamless integration of community and academic partnerships. Our commitment to train a multi-faceted workforce, provide vital resources to researchers, and improve the efficiency of research processes, promotes the collaborative team science framework needed to translate research discoveries into effective interventions that address current and future health concerns.
We provide over 70 different services and programs focused on education and training, seed funding, bioinformatics, biostatistics, clinical research, lifespan research and special populations, regulatory knowledge and bioethics, an off-site community facility and health informatics websites.
- The purpose of the Informatics Common Metric is to increase interoperability of data across the consortium. This metric supports the following NCATS strategic objective “Develop interoperable and integrative biomedical informatics resources to facilitate translational innovation in disease prevention, diagnosis and treatment.” The Common Metrics Initiative team is disseminating this actionable
The webcast provides examples of how data interoperability was used in the N3C program for the COVID-19 pandemic.
- June 16, 2021
Throughout the pandemic, doctors have seen evidence that men with COVID-19 fare worse, on average, than women with the infection. One theory is that hormonal differences between men and women may make men more susceptible to severe disease. And since men have much more testosterone than women, some scientists have speculated that high levels of testosterone may be to blame. But a new study from
- June 16, 2021
Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine in St. Louis. Such cells could persist for a lifetime, churning out antibodies all the while. The findings, published May 24 in the journal Nature, suggest
- June 14, 2021N3C Orientation Sessions A & B will now be offered just once-per-month (once for session A and once for session B). Sessions A & B will continue to alternate on a rotating basis. View the N3C Calendar for scheduled days and times. Previously recorded sessions can still be accessed on demand on the N3C Presentations & Webinars page of the website.
- Journal of Clinical Oncology
- June 10, 2021People who successfully fight off COVID-19 without showing symptoms have much higher levels of IgG antibodies against the virus’s spike protein than do patients who were hospitalized with COVID-19, reports a research team led by Shikhar Mehrotra, Ph.D., of the Medical University of South Carolina (MUSC) in a recent issue of iScience. The researchers screened for the IgG antibody to the viral spike
- June 07, 2021The N3C article authored by Noha Sharafeldin, MD, PhD, MSc, et al has been published in the Journal of Clinical Oncology. The authors assembled the largest nationally representative cohort of patients with cancer and COVID-19 to date and identified demographic and clinical factors associated with increased all-cause mortality in patients with cancer. See Outcomes of COVID-19 in Patients With
- May 28, 2021Our ambassador for Postgraduate Education shares his work which examines how value-based healthcare strategy can transform delivery and promote health equity. Junaid Nabi, MD, MPH, serves on a team of “ambassadors” who introduce our courses and training programs to faculty and scientists, both within and outside of Harvard University. A public health researcher and medical journalist, he is
- May 28, 2021A leader in Informatics and creator of Harvard Catalyst Profiles discusses his innovative work to make COVID-19 research data available to the world. Griffin Weber, MD, PhD is the co-faculty lead for Harvard Catalyst’s Informatics team. He’s an associate professor of medicine and biomedical informatics at Harvard Medical School and at Beth Israel Deaconess Medical Center (BIDMC), where he directs
- May 26, 2021If you missed the webinar on Weds May 13th presented by Kenneth Gersing, MD, Director of Informatics NCATS DCI entitled Studying COVID-19 Using Real-World Data: Lessons Learned and Steps Forward After One Year of the National COVID Cohort Collaborative (N3C), you can now access the recording. Topics include: • Lessons learned after one year of studying COVID-19 using real-world data • Future
- May 26, 2021Researchers with University of Iowa Health Care are working to identify ways to overcome access issues among migrant and seasonal farmworkers.
- -Stanford University
Join Stanford Medicine | Office of Community Engagement for a COVID-19 COMMUNITY TOWN HALL this Thursday, May 27th | 3:30-5:00 PM PDT What's on the horizon? Address Emerging Issues Around COVID-19 Vaccines for Children, Variants of the Virus, and Mask Guidelines Online Event | Register Today! Spanish Translation Available on Zoom Only FEATURED SPEAKERS • Yvonne (Bonnie) A. Maldonado, MD, FAAP
- -Center for Data to HealthNoha Sharafeldin, MBBCh, MSc, PhD co-leads the Oncology Domain Team of the National COVID Cohort Collaborative (N3C). Dr. Sharafeldin will present the abstract titled: Outcomes of COVID-19 in Cancer Patients: Report From the National COVID Cohort Collaborative (N3C) at the American Society of Clinical Oncology (ASCO) annual meeting. The oral abstract is part of the Care Delivery and Regulatory
- May 20, 2021Paul “Pee-J” Beverly doesn’t remember being airlifted to VCU Health from Lexington, Va., last fall. In fact, he doesn’t remember much of his COVID-19 experience at all. But his girlfriend, Angela Griffin, does. “It was one of the scariest things I’ve ever been through,” she said. “Not being able to see him, barely being able to talk to him. And knowing it was touch and go. They pretty much
- May 19, 2021
In vaccine clinical trials, the Pfizer and Moderna COVID-19 vaccines were shown to be about 95% effective in preventing COVID-19. Now a study from the Centers for Disease Control and Prevention uses real-world data to show that indeed, those who are 65 years and older who are fully vaccinated are 94% percent less likely to be hospitalized for COVID-19 than those who have not been vaccinated
- -University Of Southern California
This virtual town hall event is open to all and will feature a member of the LGBTQIA community as well as top LGBTQIA health experts from USC, CHLA, and St. John’s Well Child and Family Center. Not California-specific, so please share widely! WHEN? Tuesday, May 25 from 6-7:30pm PST Register for the town hall and submit your questions here: https://usc.qualtrics.com/jfe/form/SV_eXovlRQCqbai23k Dial
- May 11, 2021Seemingly overnight, the entire world zeroed in on a single research topic. The World Health Organization had already declared COVID-19 a global health emergency, and in CTSA Program hubs across the United States, health and medical experts faced the same urgent challenge: the speed and efficiency of today’s technologically-driven global economy that enabled the Coronavirus to spread as quickly as
- -University of Nebraska Medical CenterKenneth Gersing Director of Informatics Division of Clinical Innovation National Center for Advancing Translational Sciences National Institutes of Health Since 2020, Dr. Gersing has co-led the National COVID Cohort Collaborative (N3C).N3C is a partnership among the NCATS-supported Clinical and Translational Science Awards (CTSA) Program hubs, the National Center for Data to Health (CD2H), and the
- -University Of Southern California
The SC CTSI is hosting a virtual workshop about the COVID-19 vaccine where doctors answer YOUR questions and concerns! Leadership from the faith community will also be in attendance to talk about the vaccine and religion. ALL are welcome! Happening Wednesday 5/12 starting at 5 p.m. via Zoom. Please share widely! Dial-In Information Register and Submit your Questions Here: https://rebrand.ly
- May 10, 2021
Session recordings and slide presentations are now available from the DC CTSA Consortium's 2021 DC CTSA Spring Regulatory Update & Hot Topics in Clinical and Translational Research. Moving Swiftly to Combat the COVID-19 Global Health Crisis (4/23/21) Keynote, featuring David Diemert, MD, FRCP(C) Panel 1: COVID-19 Vaccine Research, Recruitment, and Testing Panel 2: Regulatory Issues Related to
- May 07, 2021
A new study by WashU Med maternal-fetal medicine researchers shows that the novel coronavirus infects maternal and fetal cells in the placenta and alters the balance of hormones that regulate blood pressure. This finding, published in the journal Med, helps explain why coronavirus infection has been linked to serious pregnancy complications, such as preeclampsia, that threaten the health of both
- May 06, 2021For the past year, researchers have been pursuing possibilities for the repurposing of existing drugs that can effectively disrupt COVID-19 disease processes. Electronic health record (EHR) data from the N3C Data Enclave were used to produce a recent preprint published in medRxiv on April 6, 2021 titled Drug repositioning candidates identified using in-silico quasi-quantum molecular simulation
- -Children's Research Institute
This annual symposium celebrates the partnership between Children’s National Hospital (CNH) and the National Institute of Allergy and Infectious Diseases (NIAID). Established in 2017, the CNH-NIAID partnership focuses on advancing the health of children with allergic, immunologic, and infectious diseases through collaborative research and education. This year, the Symposium will be held on
- -Center for Data to HealthNot sure how to go about identifying which patients in the N3C Data Enclave have had COVID-19? Want to get your COVID+ patient counts to match the numbers on the Enclave homepage dashboard? The Enclave Users’ Group (EUG) has been created as a community-focused forum where members can share practical information on techniques, tips, and methods in the N3C Data Enclave. Each session will have one or
- University Of Southern California
COVID-19 has thrown a wrench into research conduct, forcing hospitals and universities to transfer their research plans, data collection procedures, survey dissemination processes, and participant engagement methods quickly and nimbly to online venues. In addition, the state of research operations has changed dramatically due to the pandemic. This guide provides key considerations for ensuring
- -University of Maryland
Have you wondered how to make data work for you, how to make sense of the deluge of data, and how to use data to help in your day-to-day clinical, policy, and other decisions? If this sounds like you, mark your calendar to attend "Data Science to Power Implementation with Social Determinants of Health," the inaugural conference presented by the Data to Action! program. All registrants, including
- April 26, 2021The loss of smell or taste for COVID-19 survivors who experience those symptoms frequently leads to depression, a loss of appetite and a decreased enjoyment of life, according to an ongoing Virginia Commonwealth University study. In the study of quality of life and safety for those with loss of smell or taste related to COVID-19, 43% of participants reported feeling depressed. Of the 322
- Journal of Clinical and Translational Science
The 2020 COVID-19 pandemic has had a profound impact on the clinical research enterprises at the 60 Clinical and Translational Science Award (CTSA) Hubs throughout the nation.